Results 51 to 60 of about 35,251 (213)

Correlation of an epigenetic mitotic clock with cancer risk. [PDF]

, 2016
BACKGROUND: Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be influenced by extrinsic factors ...
Beck, Stephan, Kuh, Diana, Leslie, R David, Paul, Dirk S, Rakyan, Vardhman K, Teschendorff, Andrew E, Widschwendter, Martin, Wong, Andrew, Yang, Zhen, Zheng, Shijie C   +9 more
core   +3 more sources

Rejuvenation by cell reprogramming: A new horizon in gerontology [PDF]

, 2018
The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here,
Brown, Oscar Alfredo, Canatelli Mallat, Martina, Chiavellini, Priscila, Goya, Rodolfo Gustavo, Hereñú, Claudia Beatriz, Lehmann, Marianne   +5 more
core   +2 more sources

Estimating Polar Bear (Ursus maritimus) Age Based on an Epigenetic DNA Methylation Clock

Ecology and Evolution
Knowledge of animal age is essential to wildlife managers for obtaining meaningful and accurate insights into demographic parameters. A common approach to aging wildlife, including bears (Ursus spp.), has been extracting a tooth during physical capture ...
Susannah P. Woodruff, Milda Milčiūtė, Juozas Gordevičius, Robert Brooke, Todd C. Atwood   +4 more
doaj   +1 more source

Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]

, 2017
The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana, Leinweber, Brinja, Oster, Henrik, Tsang, Anthony H.   +3 more
core   +2 more sources

Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial)

Scientific Reports
Plasmapheresis is a medical procedure that separates plasma from blood cells, potentially removing pro-aging factors from circulation. Some studies suggest it may have rejuvenating effects by altering biomarkers of aging, but evidence on its impact on ...
Pavel Borsky, Drahomira Holmannova, Helena Parova, Steve Horvath, Petr Sramek, Robert T. Brooke, Milda Milciute, Juozas Gordevicius, Zdenek Fiala, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Ivana Baranova, Natalia Matyasovska, Lenka Borska   +14 more
doaj   +1 more source

Epigenetic clock analysis in long-term meditators [PDF]

Psychoneuroendocrinology, 2017
In this paper, we examined whether meditation practice influences the epigenetic clock, a strong and reproducible biomarker of biological aging, which is accelerated by cumulative lifetime stress and with age-related chronic diseases. Using the Illumina 450K array platform, we analyzed the DNA methylome from blood cells of long-term meditators and ...
Chaix, Raphaëlle, Alvarez-López, Maria Jesús, Fagny, Maud, Lemee, Laure, Regnault, Béatrice, Davidson, Richard, Lutz, Antoine, Kaliman, Perla   +7 more
openaire   +3 more sources

DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples

Communications Biology
This study aims to evaluate differences between Infinium MethylationEPIC (EPICv1) and Infinium MethylationEPICv2 (EPICv2) arrays in estimating DNAm age with eleven DNAm clocks using buffy coat, peripheral blood mononuclear cell (PBMC), and saliva from 16
Jian Hua Tay, Yi Ern Chew, Weilan Wang, Zhi Meng Lim, Lihuan Guan, Rajkumar Dorajoo, Brian K. Kennedy, Robert Brooke, Juozas Gordevicius, Steve Horvath, Elena Sandalova, Andrea B. Maier   +11 more
doaj   +1 more source

Multi-tissue DNA methylation age predictor in mouse

Genome Biology, 2017
Background DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an underlying ageing process.
Thomas M. Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, BI Ageing Clock Team, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik   +7 more
doaj   +1 more source

Empowering precision medicine through high performance computing clusters [PDF]

, 2018
The role of High Performance Computing (HPC) in Medicine is greatly increase in these last years, moving from basic research to the clinics. With the advent of Next Generation Sequencing (NGS) technologies, diverse areas of human health have been ...
Castrignanò Tiziana, Chillemi Giovanni, Parisi Valerio   +2 more
core   +3 more sources

Effects of Maternal Vitamin D3 Supplementation on Offspring Epigenetic Clock of Gestational Age at Birth: A Post-hoc Analysis of a Randomized Controlled Trial

Epigenetics, 2020
Vitamin D could be beneficial for healthy ageing in humans. We previously found that vitamin D supplementation may slow down epigenetic ageing in young African American adults.
Li Chen, Carol L. Wagner, Yanbin Dong, Xiaoling Wang, Judith R. Shary, Ying Huang, Bruce W. Hollis, Haidong Zhu   +7 more
doaj   +1 more source