Results 71 to 80 of about 317,209 (276)
The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models [PDF]
, 2010 Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock.
Andrew J Millar +15 more
core +1 more source
Mammalian circadian clock and metabolism – the epigenetic link [PDF]
Journal of Cell Science, 2010 Circadian rhythms regulate a wide variety of physiological and metabolic processes. The clock machinery comprises complex transcriptional–translational feedback loops that, through the action of specific transcription factors, modulate the expression of as many as 10% of cellular transcripts. This marked change in gene expression necessarily implicates
Bellet M. M., Sassone-Corsi P.
openaire +3 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Distinct epigenetic aging in sporadic and hereditary neuroendocrine neoplasms
Clinical EpigeneticsBackground Epigenetic clocks assess DNA aging based on DNA methylation. We aimed to study the utility of methylation clocks in understanding the distinct characteristics of sporadic and hereditary neuroendocrine neoplasms (NEN).
Shiri Weinstein +2 more
doaj +1 more source
Designing Epigenetic Clocks for Wildlife Research
Molecular Ecology ResourcesABSTRACT The applications of epigenetic clocks – statistical models that predict an individual's age based on DNA methylation patterns – are expanding in wildlife conservation and management. This growing interest highlights the need for field‐specific design best practices.
Levi Newediuk +5 more
openaire +3 more sources
A new timepiece: an epigenetic mitotic clock
Genome Biology, 2016 A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.
Christensen, Brock C., Kelsey, Karl T.
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Genome Biology, 2017 Background Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by ...
Tina Wang +9 more
doaj +1 more source
Modeling of thermally induced skew variations in clock distribution network [PDF]
, 2011 Clock distribution network is sensitive to large thermal gradients on the die as the performance of both clock buffers and interconnects are affected by temperature.
Macii, Alberto +5 more
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