Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]
, 2015 The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Farjo, Bessam +4 more
core +4 more sources
Frontiers in NeuroscienceIntroductionAging is the primary risk factor for sporadic Alzheimer's disease. Chronic low-grade inflammation associated with aging drives cognitive impairment through multiple mechanisms involving oxidative stress, insulin resistance, and dysregulation ...
Christopher L. Reading +16 more
doaj +1 more source
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. [PDF]
, 2018 An algorithm assessing the methylation levels of 353 informative CpG sites in the human genome permits accurate prediction of the chronologic age of a subject.
Bedard, Jenna +7 more
core +1 more source
Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation
, 2011 We show that the effect of stress on the reproductive fitness of noisy cell populations can be modelled as first-passage time problem, and demonstrate that even relatively short-lived fluctuations in gene expression can ensure long-term survival of a ...
Abdennur, Nezar +2 more
core +1 more source
Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]
, 2018 The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core +1 more source
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
, 2020 The European map butterfly (Araschnia levana ) is a well‐known example of seasonal polyphenism because the spring and summer imagoes exhibit distinct morphological phenotypes.
Baudach, A. +3 more
core +1 more source
Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]
, 2018 Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter +7 more
core +1 more source
Primate phylogeny: molecular evidence for a pongid clade excluding humans and a prosimian clade containing tarsiers [PDF]
, 2009 Interpretations of molecular data by the modern evolution theory are often sharply inconsistent with paleontological results. This is to be expected since the theory is only true for microevolution and yet fossil records are mostly about macroevolution.
Shi Huang
core +1 more source
Organellar carbon metabolism is co-ordinated with distinct developmental phases of secondary xylem [PDF]
, 2019 Subcellular compartmentation of plant biosynthetic pathways in the mitochondria and plastids requires coordinated regulation of nuclear encoded genes, and the role of these genes has been largely ignored by wood researchers. In this study, we constructed
Fierro Gutierrez, Ana Carolina Elisa +4 more
core +2 more sources