Results 91 to 100 of about 317,209 (276)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohortsResearch in context

EBioMedicine, 2019
Background: Measures based on DNA methylation, epigenetic clocks, have recently gained attraction as predictors of mortality and age-related pathologies. However, the origins of variation in these measures are not well understood.
Juulia Jylhävä, Jacob Hjelmborg, Mette Soerensen, Elizabeth Munoz, Qihua Tan, Ralf Kuja-Halkola, Jonas Mengel-From, Kaare Christensen, Lene Christiansen, Sara Hägg, Nancy L. Pedersen, Chandra A. Reynolds   +11 more
doaj   +1 more source

Epigenetic clock: a promising mirror of ageing [PDF]

The Lancet Healthy Longevity, 2021
Zuyun Liu, Yimin Zhu
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Epigenetic regulation of adaptive responses of forest tree species to the environment [PDF]

, 2013
Epigenetic variation is likely to contribute to the phenotypic plasticity and adaptative capacity of plant species, and may be especially important for long-lived organisms with complex life cycles, including forest trees.
Maury, Stéphane, Bräutigam, Katharina, Antje Rohde, M. Ángeles Guevara, Dolores Abarca, Rohde, Antje, Fluch, S., Fluch, Silvia, Fraga, Mario F., Clément Lafon‐Placette, Johnsen, Oystein, Lafon-Placette, Clément, Jose, Gutiérrez-Marcos, Angeles Guevara, M., Campbell, Malcolm M., Fossdal, Carl G., Steven H. Strauss, Bräutigam, K., Fossdal, C. G., Abarca, Dolores, Mirouze, M., Katharina Bräutigam, Malcolm M. Campbell, Lafon-Placette, C., Vining, Kelly J., Gutierrez Marcos, Jose, Campbell, M. M., Rohde, A., Fernandez Fraga, Mario, José Gutiérrez Marcos, Marcos, J. G., Marie Mirouze, Silvia Fluch, Fraga, Mario Fernández, Cervera, María-Teresa, Díaz-Sala, Carmen, María‐Teresa Cervera, Guevara, M. Ángeles, Cervera, María Teresa, Johnsen, Øystein, Strauss, Steven H., Mario Fernández Fraga, Braeutigam, Katharina, Guevara, M Ángeles, Øystein Johnsen, Stéphane Maury, Mirouze, Marie, Kelly J. Vining, Johnsen, O., Vining, K. J., Carl G. Fossdal, Carmen Díaz‐Sala   +51 more
core   +1 more source

Time's up: Epigenetic clocks in plants

Current Opinion in Plant Biology
For over a decade, the animal field has led the way in using DNA methylation measurements to construct epigenetic clocks of aging. These clocks can predict organismal age with a level of accuracy that surpasses any other molecular proxy known to date. Evidence is finally emerging that epigenetic clocks also exist in plants. However, these clocks appear
Vo, Binh Thanh, Más, Paloma, Johannes, Frank   +2 more
openaire   +3 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits.

PLoS Computational Biology
BackgroundDNA methylation (DNAm) provides a window to characterize the impacts of environmental exposures and the biological aging process. Epigenetic clocks are often trained on DNAm using penalized regression of CpG sites, but recent evidence suggests ...
Dennis Khodasevich, Nina Holland, Lars van der Laan, Andres Cardenas   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source