Results 101 to 110 of about 35,251 (213)

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohortsResearch in context

EBioMedicine, 2019
Background: Measures based on DNA methylation, epigenetic clocks, have recently gained attraction as predictors of mortality and age-related pathologies. However, the origins of variation in these measures are not well understood.
Juulia Jylhävä, Jacob Hjelmborg, Mette Soerensen, Elizabeth Munoz, Qihua Tan, Ralf Kuja-Halkola, Jonas Mengel-From, Kaare Christensen, Lene Christiansen, Sara Hägg, Nancy L. Pedersen, Chandra A. Reynolds   +11 more
doaj   +1 more source

Data from <i>CLOCK</i> in Breast Tumorigenesis: Genetic, Epigenetic, and Transcriptional Profiling Analyses

, 2023
Aaron E. Hoffman, Chunhui Yi, Tongzhang Zheng, Richard G. Stevens, Derek Leaderer, Yawei Zhang, Theodore R. Holford, Johnni Hansen, Jennifer Paulson, Yong‐Guan Zhu   +9 more
openalex   +1 more source

A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits.

PLoS Computational Biology
BackgroundDNA methylation (DNAm) provides a window to characterize the impacts of environmental exposures and the biological aging process. Epigenetic clocks are often trained on DNAm using penalized regression of CpG sites, but recent evidence suggests ...
Dennis Khodasevich, Nina Holland, Lars van der Laan, Andres Cardenas   +3 more
doaj   +1 more source

Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults

Molecular Pain, 2019
Gerontological research reveals considerable interindividual variability in aging phenotypes, which has motivated research efforts to identify “aging biomarkers.” Aging biomarkers are used to calculate biological age, which are better predictors of ...
Yenisel Cruz-Almeida, Puja Sinha, Asha Rani, Zhiguang Huo, Roger B Fillingim, Thomas Foster   +5 more
doaj   +1 more source

Epigenetic aging clocks in mice and men

Genome Biology, 2017
Genome biology 18(1), 107 (2017).
openaire   +4 more sources

Requirements for efficient cell-type proportioning: regulatory timescales, stochasticity and lateral inhibition

, 2015
The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell-types. This developmental differentiation process typically involves intracellular regulatory and stochastic mechanisms to ...
Kaneko, Kunihiko, Pfeuty, Benjamin
core   +1 more source

ComputAgeBench: Epigenetic Aging Clocks Benchmark

Proceedings of the 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining V.2
AbstractThe success of clinical trials of longevity drugs relies heavily on identifying integrative health and aging biomarkers, such as biological age. Epigenetic aging clocks predict the biological age of an individual using their DNA methylation profiles, commonly retrieved from blood samples.
Dmitrii Kriukov, Evgeniy Efimov, Ekaterina Kuzmina, Anastasiia Dudkovskaia, Ekaterina E. Khrameeva, Dmitry V. Dylov   +5 more
openaire   +1 more source

Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer

Cancer Biology & Medicine
Objective: Epigenetic abnormalities have a critical role in breast cancer by regulating gene expression; however, the intricate interrelationships and key roles of approximately 400 epigenetic regulators in breast cancer remain elusive.
Yumei Wang, Haiyan Wang, Wei Shao, Yuhui Chen, Yu Gui, Chao Hu, Xiaohong Yi, Lijun Huang, Shasha Li, Dong Wang   +9 more
doaj   +1 more source

The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

, 2021
Lauren Schmitz, Wei Zhao, Scott M. Ratliff, Julia A. Goodwin, Jiacheng Miao, Qiongshi Lu, Xiuqing Guo, Kent D. Taylor, Jingzhong Ding, Yongmei Liu, Morgan E. Levine, Jennifer A. Smith   +11 more
openalex   +1 more source

Epigenetic clocks, sex markers, and age-class diagnostics in three harvested large mammals [PDF]

, 2023
Natalie Czajka, Joseph M. Northrup, Meaghan J. Jones, Aaron B. A. Shafer   +3 more
openalex   +1 more source