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Inverse relationship between genetic diversity and epigenetic complexity [PDF]
, 2008 Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core +1 more source
Circadian clocks, epigenetics, and cancer [PDF]
Current Opinion in Oncology, 2015 The interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates the circadian clock in cancer survival and proliferation pathways.
Masri, Selma +2 more
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Epigenetic Clock: DNA Methylation in Aging [PDF]
Stem Cells International, 2020 Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regulators involved in this process ...
Shuang Jiang, Yuchen Guo
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Dynamic epigenetic age mosaicism in the human atherosclerotic artery
PLoS ONE, 2022 Accelerated epigenetic ageing, a promising marker of disease risk, has been detected in peripheral blood cells of atherosclerotic patients, but evidence in the vascular wall is lacking.
Silvio Zaina +3 more
doaj +3 more sources
Scientific Reports, 2023 Age structure information of animal populations is fundamental to their conservation and management. In fisheries, age is routinely obtained by counting daily or annual increments in calcified structures (e.g., otoliths) which requires lethal sampling ...
Benjamin Mayne +11 more
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Characteristics of Epigenetic Clocks Across Blood and Brain Tissue in Older Women and Men
Frontiers in Neuroscience, 2021 Epigenetic clocks are among the most promising biomarkers of aging. It is particularly important to establish biomarkers of brain aging to better understand neurodegenerative diseases.
Francine Grodstein +8 more
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Epigenetic clock and methylation studies in cats [PDF]
GeroScience, 2021 Abstract Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles underpinning them appear to be conserved even in ...
Ken Raj +8 more
openaire +4 more sources
Nature Communications, 2022 The temporal development of tissues and organs may be defined by the genome-wide epigenetic and transcriptional state functioning as the clock. Here the authors found that Fbl, a ribosomal RNA methyltransferase, potentially behaves as a clock during ...
Quan Wu +7 more
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Simulating Future GPS Clock Scenarios With Two Composite Clock Algorithms [PDF]
, 2010 Using the GPS Toolkit, the GPS constellation is simulated using thirty-one satellites (SV) and a ground network of seventeen monitor stations (MS). At every 15 minute measurement epoch, the monitor stations measure the time signals of all satellites ...
Greenhall, Charles +5 more
core +1 more source
Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus
Frontiers in Genetics, 2022 Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited.
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
doaj +1 more source