Results 121 to 130 of about 72,064 (292)
Light at night disrupts biological clocks, calendars, and immune function. [PDF]
Semin Immunopathol, 2022 Walker WH +5 more
europepmc +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
DNA methylation clocks and cognitive status among older adults in the US, NHANES 1999–2002
Epigenetics ReportsBiological aging, measured using DNA methylation, is a potential biomarker for cognitive health outcomes. We evaluated associations between DNA methylation clocks and cognition in a nationally representative sample of adults aged 60+ in the National ...
Erika Walker +5 more
doaj +1 more source
Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm. [PDF]
Front Biosci (Landmark Ed), 2021 Maiese K.
europepmc +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
BMC GenomicsAge is a major risk factor for various diseases, such as cancer, cardiovascular conditions, and neurodegenerative diseases. However, chronological age, the simple number of years one has lived, does not capture individual health differences, prompting ...
Akshay Anand +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Homo sapiens May Incorporate Daily Acute Cycles of "Conditioning-Deconditioning" to Maintain Musculoskeletal Integrity: Need to Integrate with Biological Clocks and Circadian Rhythm Mediators. [PDF]
Int J Mol Sci, 2022 Hart DA, Zernicke RF, Shrive NG.
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source