Biological switches and clocks [PDF]
Journal of The Royal Society Interface, 2008 To introduce this special issue on biological switches and clocks, we review the historical development of mathematical models of bistability and oscillations in chemical reaction networks. In the 1960s and 1970s, these models were limited to well-studied biochemical examples, such as glycolytic oscillations and cyclic AMP signalling.
Tyson, John J +4 more
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DNA methylation markers of age(ing) in non-model animals. [PDF]
, 2023 Inferring the chronological and biological age of individuals is fundamental to population ecology and our understanding of ageing itself, its evolution, and the biological processes that affect or even cause ageing.
Annabel J. Slettenhaar +6 more
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Computing with biological switches and clocks [PDF]
Natural Computing, 2018 The complex dynamics of biological systems is primarily driven by molecular interactions that underpin the regulatory networks of cells. These networks typically contain positive and negative feedback loops, which are responsible for switch-like and oscillatory dynamics, respectively.
Andrew Phillips +8 more
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A 2-dimensional Geometry for Biological Time [PDF]
, 2011 This paper proposes an abstract mathematical frame for describing some features of biological time. The key point is that usual physical (linear) representation of time is insufficient, in our view, for the understanding key phenomena of life, such as ...
Bailly +29 more
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Rhythms of Locomotion Expressed by Limulus polyphemus, the American Horseshoe Crab: II. Relationship to Circadian Rhythms of Visual Sensitivity [PDF]
, 2008 In the laboratory, horseshoe crabs express a circadian rhythm of visual sensitivity as well as daily and circatidal rhythms of locomotion. The major goal of this investigation was to determine whether the circadian clock underlying changes in visual ...
Bedford, Lisa +2 more
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Peripheral circadian oscillators: interesting mechanisms and powerful tools [PDF]
, 2008 The lives of plants, animals, and human beings are all regulated by circadian clocks. In mammals, 24-hour rhythms of physiology and behavior are directed by a master clock in the suprachiasmatic nucleus (SCN) of the brain hypothalamus, which in turn ...
Brown, S A, Cuninkova, L
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Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy. [PDF]
, 2019 MotivationMultiple biological clocks govern a healthy pregnancy. These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of pregnancy.
Agard, Bruno +42 more
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A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk [PDF]
, 2022 Biological age (BA), a measure of functional capacity and prognostic of health outcomes that discriminates between individuals of the same chronological age (chronAge), has been estimated using a variety of biomarkers.
Esko, Tõnu +10 more
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No association between frailty index and epigenetic clocks in Italian semi-supercentenarians [PDF]
, 2021 Centenarians experience successful ageing, although they still present high heterogeneity in their health status. The frailty index is a biomarker of biological age, able to capture such heterogeneity, even at extreme old age.
Arosio B. +10 more
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Biological clock: Biological clocks may modulate drug addiction [PDF]
European Journal of Human Genetics, 2005 A recent study by McClung's group (2005),1 expanding on an earlier report,2 provides mechanistic insight to the timekeeper gene, Clock, which may regulate dopaminergic transmission and cocaine reward. This work provides further evidence that cocaine-induced effects have circadian influences.
Mary Jeanne Kreek +2 more
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