Results 11 to 20 of about 69,526 (310)

Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates? [PDF]

Frontiers in Genetics
Certain aspects of animal ageing can be quantified using molecular clocks or machine learning algorithms that are trained on specific omics data, with epigenetic clocks based on DNA methylation (DNAm) garnering the most attention.
Ryszard Maleszka
doaj   +2 more sources

Genetic clock of biologic rhythms [PDF]

Journal of Cellular and Molecular Medicine, 2003
AbstractBiologic rhythms are tighly regulated in all species, in order to addapt to circadian variations of light, temperature and other biological related living conditions. The intrinsic mechanisms of rhythm regulation from every cell to a whole organism is embedded into the genetic clockwork.
Corin Badiu
openalex   +4 more sources

Metabolomic-based aging clocks [PDF]

npj Metabolic Health and Disease
Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks.
A. Ibáñez de Opakua, R. Conde, A. de Diego, M. Bizkarguenaga, N. Embade, S. C. Lu, J. M. Mato, O. Millet   +7 more
doaj   +2 more sources

Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers [PDF]

Clinical Epigenetics
Background The sex chromosome aneuploidies Turner syndrome (45,X; TS) and Klinefelter syndrome (47,XXY; KS) are associated with aging-related comorbidities, reduced life expectancy and genome-wide DNA methylation changes.
Emma B. Hasselholm, Jesper Just, Simon Chang, Anne Skakkebæk, Claus Højbjerg Gravholt   +4 more
doaj   +2 more sources

Nutritional factors regulating behavior and biological clocks [PDF]

Archives of Endocrinology and Metabolism, 2021
Licio A. Velloso
doaj   +2 more sources

Biological clocks and physical functioning in monozygotic female twins [PDF]

BMC Geriatrics, 2018
Background Biomarkers of biological aging – DNA methylation age (DNAm age) and leukocyte telomere length (LTL)– correlate strongly with chronological age across the life course.
Elina Sillanpää, Eija K. Laakkonen, Elina Vaara, Taina Rantanen, Vuokko Kovanen, Sarianna Sipilä, Jaakko Kaprio, Miina Ollikainen   +7 more
doaj   +2 more sources

Biological clocks: The coming of age

International Journal of Applied and Basic Medical Research, 2012
Life evolved on earth slowly over a few billions of years. During this time, and before, the earth has been rotating around its own tilted axis and simultaneously revolving around the sun. Thus, it is no surprise that the periodic environmental consequences of the rotation (day and night), the tilt (changing day length) and of the revolution (seasons ...
ChandrashekharV Apte
openalex   +5 more sources

Blood transcriptomic associations of epigenetic age in adolescents [PDF]

Epigenetics
Epigenetic aging in early life remains poorly characterized, and patterns of gene expression can provide biologically meaningful insights. Blood DNA methylation was measured using the Illumina EPICv1.0 array and RNA sequencing was performed in blood in ...
Dennis Khodasevich, Anne K Bozack, Saher Daredia, Julianna Deardorff, Kim G Harley, Brenda Eskenazi, Weihong Guo, Nina Holland, Andres Cardenas   +8 more
doaj   +2 more sources

Light at night disrupts biological clocks, calendars, and immune function. [PDF]

Semin Immunopathol, 2022
Walker WH, Bumgarner JR, Becker-Krail DD, May LE, Liu JA, Nelson RJ.   +5 more
europepmc   +3 more sources

MethAgingDB: a comprehensive DNA methylation database for aging biology [PDF]

Scientific Data
Accurately quantifying biological age is crucial for understanding the mechanisms of aging and developing effective interventions. Molecular aging clocks, particularly epigenetic clocks that use DNA methylation data to estimate biological age, have ...
Siyu Li, Songming Tang, Haocheng Ma, Haixin Wang, Shengquan Chen   +4 more
doaj   +2 more sources