Results 41 to 50 of about 72,064 (292)

How to Synchronize Biological Clocks [PDF]

Journal of Computational Biology, 2009
This paper is concerned with a novel algorithm to study networks of biological clocks. A new set of conditions is established that can be used to verify whether an existing network synchronizes or to give guidelines to construct a new synthetic network of biological oscillators that synchronize.
G. Russo, DI BERNARDO, MARIO
openaire   +5 more sources

Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells [PDF]

, 2009
Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases
Dong, Guogang, Golden, Susan S., Pando, Bernardo Fabian, van Oudenaarden, Alexander, Yang, Qiong, Ph. D. Massachusetts Institute of Technology   +4 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity

Cell Reports
Summary: Ribosome composition is dynamic, shifting with cell state and stress, but whether it varies with circadian time is unknown. Here, we uncover circadian clock-driven changes in ribosome composition in Neurospora crassa.
Teresa M. Lamb, Kathrina D. Castillo, Rachel Porter, Cheng Wu, Samuel O. Purvine, Griffin Best, Erika Zink, Ebimobowei O. Preh, Lunda Shen, Matthew S. Sachs, Deborah Bell-Pedersen   +10 more
doaj   +1 more source

Complementary approaches to understanding the plant circadian clock [PDF]

, 2010
Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far.
A. Aziz, A. Duguid, A. Hinton, Bio-PEPA Home Page, C. Baier, Carl Troein, D. Gonze, D.T. Gillespie, E. Derelle, E.M. Clarke, Emanuela Merelli, F. Ciocchetta, F. Corellou, H. Li, H.L.S. Younes, J. Heath, J.C. Dunlap, J.S. O'Neill, L. Loewe, L. Loewe, Laurence Loewe, M.A. Jones, Maria Luisa Guerriero, O.E. Akman, O.E. Akman, Ozgur E. Akman, Paola Quaglia   +26 more
core   +4 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?

Frontiers in Genetics
Certain aspects of animal ageing can be quantified using molecular clocks or machine learning algorithms that are trained on specific omics data, with epigenetic clocks based on DNA methylation (DNAm) garnering the most attention.
Ryszard Maleszka
doaj   +1 more source

Patterns of Activity Expressed by Juvenile Horseshoe Crabs [PDF]

, 2013
Adult American horseshoe crabs, Limulus polyphemus, possess endogenous circadian and circatidal clocks controlling visual sensitivity and locomotion, respectively.
Chabot, Christopher C., Dubofsky, Elizabeth A., Simpson, S. D., Watson, Winsor H., III   +3 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

Epigenetics, 2022
Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells. Their success as a measure of biological ageing has prompted research on the connection between epigenetic pathways of ageing and the socioeconomic gradient in ...
Lauren L. Schmitz, Wei Zhao, Scott M. Ratliff, Julia Goodwin, Jiacheng Miao, Qiongshi Lu, Xiuqing Guo, Kent D. Taylor, Jingzhong Ding, Yongmei Liu, Morgan Levine, Jennifer A. Smith   +11 more
doaj   +1 more source