Results 41 to 50 of about 5,783,416 (253)

Decoding aging clocks from a metabolomic perspective [PDF]

PeerJ
Biological age quantifies functional decline beyond chronological aging; however, current epigenetic clocks exhibit limitations in resolving dynamic metabolic fluctuations and tissue-specific aging trajectories. Metabolomics emerges as a pivotal solution,
Xueyu Qu, Qiqi You, Menglin Fan, Shaoyong Xu   +3 more
doaj   +2 more sources

Performance analysis of probabilistic timed automata using digital clocks [PDF]

, 2006
Probabilistic timed automata, a variant of timed automata extended with discrete probability distributions, is a modelling formalism suitable for describing formally both nondeterministic and probabilistic aspects of real-time systems, and is amenable to
Kwiatkowska, M., Parker, D., Norman, G., Sproston, J., Sproston, Jeremy James   +4 more
core   +1 more source

Birth weight and maternal energy status during pregnancy as predictors of epigenetic age acceleration in young adults from metropolitan Cebu, Philippines

Epigenetics, 2022
Epigenetic clocks quantify regular changes in DNA methylation that occur with age, or in relation to biomarkers of ageing, and are strong predictors of morbidity and mortality.
Christopher W. Kuzawa, Calen P. Ryan, Linda S. Adair, Nanette R. Lee, Delia B. Carba, Julia L. MacIsaac, Kristy Dever, Parmida Atashzay, Michael S. Kobor, Thomas W. McDade   +9 more
doaj   +1 more source

New Insights Into Cancer Chronotherapies

Frontiers in Pharmacology, 2021
Circadian clocks participate in the coordination of various metabolic and biological activities to maintain homeostasis. Disturbances in the circadian rhythm and cancers are closely related.
Jingxuan Zhou, Jingxuan Zhou, Jingxuan Zhou, Jiechen Wang, Jiechen Wang, Jiechen Wang, Xiaozhao Zhang, Xiaozhao Zhang, Qingming Tang, Qingming Tang, Qingming Tang   +10 more
doaj   +1 more source

Towards Cancer Theory – Circadian and 11-Day Biological Clocks [PDF]

Middle East Journal of Cancer, 2021
Background: In the current study, we used the information-hierarchical system approach to examine human metabolism. Metabolism hierarchical structure, beginning from enzyme level, is controlled by the established information principle and divine section ...
Yuri Kirsta, Dmitry Kirsta
doaj   +1 more source

Reciprocity Between Robustness of Period and Plasticity of Phase in Biological Clocks. [PDF]

Physical Review Letters, 2015
Circadian clocks exhibit the robustness of period and plasticity of phase against environmental changes such as temperature and nutrient conditions. Thus far, however, it is unclear how both are simultaneously achieved.
Tetsuhiro S. Hatakeyama, K. Kaneko
semanticscholar   +1 more source

Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration

Frontiers in Medicine, 2022
Age-Related Macular Degeneration (AMD) is a bilateral ocular condition resulting in irreversible vision impairment caused by the progressive loss of photoreceptors in the macula, a region at the center of the retina. The progressive loss of photoreceptor
Saurav Mallik, Fran Grodstein, David A. Bennett, Demetrios G. Vavvas, Bernardo Lemos, Bernardo Lemos   +5 more
doaj   +1 more source

Circadian and Geotactic Behaviors: Genetic Pleiotropy in Drosophila Melanogaster

Journal of Circadian Rhythms, 2016
Data presented in this paper test the hypotheses that Hirsch’s positive geotaxis ('Lo') and negative geotaxis ('Hi5') strains of Drosophila melanogaster (fruit fly) differ in length of the free-running circadian activity period (tau) as well as adult ...
Dale L Clayton
doaj   +1 more source

The hidden rhythms of epilepsy: exploring biological clocks and epileptic seizure dynamics

Acta Epileptologica
Epilepsy, characterized by recurrent seizures, is influenced by biological rhythms, such as circadian, seasonal, and menstrual cycles. These rhythms affect the frequency, severity, and timing of seizures, although the precise mechanisms underlying these ...
Ruili Niu, Xuan Guo, Jiao-Yang Wang, Xiaofeng Yang   +3 more
semanticscholar   +1 more source

Distinguishable DNA methylation defines a cardiac-specific epigenetic clock

Clinical Epigenetics, 2023
Background The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG).
A. Mongelli, S. Panunzi, M. Nesta, M. Gottardi Zamperla, S. Atlante, V. Barbi, V. Mongiardini, F. Ferraro, S. De Martino, L. Cis, A. Re, S. Maltese, T. Bachetti, M. T. La Rovere, F. Martelli, M. Pesce, S. Nanni, M. Massetti, A. Pontecorvi, A. Farsetti, C. Gaetano   +20 more
doaj   +1 more source