Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Clinical Epigenetics, 2023 Background The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG).
A. Mongelli +20 more
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Spontaneous circadian rhythms in a cold-Adapted natural isolate of Aureobasidium pullulans [PDF]
, 2017 Indexación: Scopus.Circadian systems enable organisms to synchronize their physiology to daily and seasonal environmental changes relying on endogenous pacemakers that oscillate with a period close to 24 h even in the absence of external timing cues. The
Bellora, N. +8 more
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Peripheral circadian oscillators: interesting mechanisms and powerful tools [PDF]
, 2008 The lives of plants, animals, and human beings are all regulated by circadian clocks. In mammals, 24-hour rhythms of physiology and behavior are directed by a master clock in the suprachiasmatic nucleus (SCN) of the brain hypothalamus, which in turn ...
Brown, S A, Cuninkova, L
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In Synch but Not in Step: Circadian Clock Circuits Regulating Plasticity in Daily Rhythms [PDF]
, 2016 The suprachiasmatic nucleus (SCN) is a network of neural oscillators that program daily rhythms in mammalian behavior and physiology. Over the last decade much has been learned about how SCN clock neurons coordinate together in time and space to form a ...
Evans, Jennifer A., Gorman, M. R.
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Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]
, 2017 Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
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Biological clock: Biological clocks may modulate drug addiction [PDF]
European Journal of Human Genetics, 2005 A recent study by McClung's group (2005),1 expanding on an earlier report,2 provides mechanistic insight to the timekeeper gene, Clock, which may regulate dopaminergic transmission and cocaine reward. This work provides further evidence that cocaine-induced effects have circadian influences.
Vadim Yuferov +2 more
openaire +1 more source
Clinical Epigenetics, 2023 Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui +8 more
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Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young [PDF]
, 2018 In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mutants
Hardin, P. E. +2 more
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iScienceSummary: Light is one of the strongest cues for entrainment of circadian clocks. While some insect species rely only on visual input, others like Drosophila melanogaster use both the visual system and the deep-brain blue-light photoreceptor cryptochrome ...
Samantha E. Iiams +6 more
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Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]
, 2015 A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M +28 more
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