Results 11 to 20 of about 698 (168)

New Insights Into Cancer Chronotherapies

Frontiers in Pharmacology, 2021
Circadian clocks participate in the coordination of various metabolic and biological activities to maintain homeostasis. Disturbances in the circadian rhythm and cancers are closely related.
Jingxuan Zhou, Jingxuan Zhou, Jingxuan Zhou, Jiechen Wang, Jiechen Wang, Jiechen Wang, Xiaozhao Zhang, Xiaozhao Zhang, Qingming Tang, Qingming Tang, Qingming Tang   +10 more
doaj   +1 more source

Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration

Frontiers in Medicine, 2022
Age-Related Macular Degeneration (AMD) is a bilateral ocular condition resulting in irreversible vision impairment caused by the progressive loss of photoreceptors in the macula, a region at the center of the retina. The progressive loss of photoreceptor
Saurav Mallik, Fran Grodstein, David A. Bennett, Demetrios G. Vavvas, Bernardo Lemos, Bernardo Lemos   +5 more
doaj   +1 more source

Circadian and Geotactic Behaviors: Genetic Pleiotropy in Drosophila Melanogaster

Journal of Circadian Rhythms, 2016
Data presented in this paper test the hypotheses that Hirsch’s positive geotaxis ('Lo') and negative geotaxis ('Hi5') strains of Drosophila melanogaster (fruit fly) differ in length of the free-running circadian activity period (tau) as well as adult ...
Dale L Clayton
doaj   +1 more source

Distinguishable DNA methylation defines a cardiac-specific epigenetic clock

Clinical Epigenetics, 2023
Background The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG).
A. Mongelli, S. Panunzi, M. Nesta, M. Gottardi Zamperla, S. Atlante, V. Barbi, V. Mongiardini, F. Ferraro, S. De Martino, L. Cis, A. Re, S. Maltese, T. Bachetti, M. T. La Rovere, F. Martelli, M. Pesce, S. Nanni, M. Massetti, A. Pontecorvi, A. Farsetti, C. Gaetano   +20 more
doaj   +1 more source

Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

Clinical Epigenetics, 2023
Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui, Fathima Humaira Amanullah, Mohamad Saad, Sara Taleb, Martina Bradic, Andre Megarbane, Ali Ait Hssain, Charbel Abi Khalil, Nady El Hajj   +8 more
doaj   +1 more source

Loss of functional cryptochrome 1 reduces robustness of 24-hour behavioral rhythms in monarch butterflies

iScience
Summary: Light is one of the strongest cues for entrainment of circadian clocks. While some insect species rely only on visual input, others like Drosophila melanogaster use both the visual system and the deep-brain blue-light photoreceptor cryptochrome ...
Samantha E. Iiams, Guijun Wan, Jiwei Zhang, Aldrin B. Lugena, Ying Zhang, Ashley N. Hayden, Christine Merlin   +6 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity

Cell Reports
Summary: Ribosome composition is dynamic, shifting with cell state and stress, but whether it varies with circadian time is unknown. Here, we uncover circadian clock-driven changes in ribosome composition in Neurospora crassa.
Teresa M. Lamb, Kathrina D. Castillo, Rachel Porter, Cheng Wu, Samuel O. Purvine, Griffin Best, Erika Zink, Ebimobowei O. Preh, Lunda Shen, Matthew S. Sachs, Deborah Bell-Pedersen   +10 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source