Results 61 to 70 of about 5,783,416 (253)

Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?

Frontiers in Genetics
Certain aspects of animal ageing can be quantified using molecular clocks or machine learning algorithms that are trained on specific omics data, with epigenetic clocks based on DNA methylation (DNAm) garnering the most attention.
Ryszard Maleszka
doaj   +1 more source

DNA methylation clocks for estimating biological age in Chinese cohorts

Protein & Cell
Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison between DNA methylation data and other omics datasets has not yet been performed.
Zi-Kai Zheng, Jia-Ming Li, Tianzi Liu, Yan-Ling Fan, Qiao-Cheng Zhai, M. Xiong, Qiao-Ran Wang, Xiao-Yan Sun, Q. Zheng, Shanshan Che, Bei-Er Jiang, Quan Zheng, Cui Wang, Li-Xiao Liu, Jia-Le Ping, Si Wang, Dan-Dan Gao, Jinlin Ye, Kuan Yang, Yue-Sheng Zuo, Shuai Ma, Yun-Gui Yang, J. Qu, Feng Zhang, Peilin Jia, Guang-Hui Liu, Weiqi Zhang   +26 more
semanticscholar   +1 more source

Biological clocks: their relevance to immune-allergic diseases

Clinical and Molecular Allergy, 2018
The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention to the importance of circadian rhythms ...
R. Paganelli, C. Petrarca, M. Di Gioacchino   +2 more
semanticscholar   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution

bioRxiv
The ability to accurately quantify biological age could help monitor and control healthy aging. Epigenetic clocks have emerged as promising tools for estimating biological age, yet they have been developed from heterogeneous bulk tissues, and are thus ...
Huige Tong, Xiaolong Guo, M. Jacques, Qi Luo, N. Eynon, Andrew E. Teschendorff   +5 more
semanticscholar   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Contextualizing aging clocks and properly describing biological age

Aging Cell
Usage of the phrase “biological age” has picked up considerably since the advent of aging clocks and it has become commonplace to describe an aging clock's output as biological age. In contrast to this labeling, biological age is also often depicted as a
Adiv A. Johnson, Maxim N. Shokhirev
semanticscholar   +1 more source

A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking

Nature Aging, 2021
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show that technical noise produces deviations up to 9 years between replicates for six prominent epigenetic ...
A. Higgins-Chen, Kyra L. Thrush, Yunzhang Wang, Christopher J Minteer, Pei-lun Kuo, Meng Wang, Peter Niimi, Gabriel Sturm, Jue Lin, A. Moore, S. Bandinelli, C. Vinkers, E. Vermetten, B. Rutten, E. Geuze, C. Okhuijsen-Pfeifer, M. van der Horst, S. Schreiter, S. Gutwinski, J. Luykx, M. Picard, L. Ferrucci, E. Crimmins, M. Boks, S. Hägg, T. Hu-Seliger, M. Levine   +26 more
semanticscholar   +1 more source

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source