How much biology is in the product? Role and relevance of biological evolution and function for bio-inspired design. [PDF]
Theory Biosci, 2022 Roth-Nebelsick A.
europepmc +1 more source
Divide and conquer? Size adjustment with allometry and intermediate outcomes
BMC Biology, 2017 Many trait measurements are size-dependent, and while we often divide these traits by size before fitting statistical models to control for the effect of size, this approach does not account for allometry and the intermediate outcome problem. We describe
Shinichi Nakagawa +4 more
doaj +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The cosmological model of eternal inflation and the transition from chance to biological evolution in the history of life: The possibility of chance emergence of the replication and translation systems, and the protein superfolds [PDF]
arXiv, 2007 Evolution of life on earth was governed, primarily, by natural selection, with major contribution of other evolutionary processes, such as neutral variation, exaptation, and gene duplication. However, for biological evolution to take off, a certain minimal degree of complexity is required such that a replicating genome encodes means for its own ...
arxiv
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Solution of the Master Equation for Bak-Sneppen Model of Biological Evolution in Finite Ecosystem [PDF]
arXiv, 1996 The master equations describing processes of biological evolution in the framework of the random neighbor Bak-Sneppen model are studied. For the eqosystem of $N$ species they are solved exactly and asymptotical behavior of this solution for large $N$ is analyzed.
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
50/500 or 100/1000 debate is not about the time frame - Reply to Rosenfeld [PDF]
arXiv, 2014 The Letter from Rosenfeld (2014, Biological Conservation) in response to Jamieson and Allendorf (2012, Trends in Ecology and Evolution) and Frankham et al. (2014, Biological Conservation) and related papers is misleading in places and requires clarification and correction. We provide those here.
arxiv
On predictions and laws in biological evolution: Is biology able to formulate general laws and develop inductive predictions as in physics or chemistry?: Is biology able to formulate general laws and develop inductive predictions as in physics or chemistry? [PDF]
EMBO Rep, 2022 Rull V.
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