Results 71 to 80 of about 1,840,126 (315)
Entropy and Entropy Production: Old Misconceptions and New Breakthroughs
Entropy, 2013 Persistent misconceptions existing for dozens of years and influencing progress in various fields of science are sometimes encountered in the scientific and especially, the popular-science literature.
Leonid M. Martyushev
doaj +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
Exploring Comparative Physiology and Evolution: Understanding Homologous Structures with Students
Current: The Journal of Marine EducationA summer course designed for high school students compared different morphological features that evolved in response to locomotion. This course, as part of the USC Leslie and Bill McMorrow Neighborhood Academic Initiative (USC NAI), provided 20 students ...
Dieuwertje J. Kast +3 more
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Is Evolution by Natural Selection the Algorithm of Biological Evolution? [PDF]
Artificial Life 13, 2012 It is tempting to be confident that we know how biological evolution works. After all, we know a mechanism capable of producing adaptation, and we understand the necessary and sufficient conditions for this to occur, and those conditions are met in natural populations – the rest is surely just details.
openaire +2 more sources
Machine learning-guided directed evolution for protein engineering [PDF]
, 2019 Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying ...
Arnold, Frances H. +2 more
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FEBS Letters, EarlyView.The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
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MicroorganismsFiloviruses are among the most lethal viral human pathogens known, with significant relevance to public health, yet their evolutionary history remains poorly resolved.
Thiago S. Messias +15 more
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Race in the Life Sciences: An Empirical Assessment, 1950-2000 [PDF]
, 2015 The mainstream narrative regarding the evolution of race as an idea in the scientific community is that biological understandings of race dominated throughout the nineteenth and twentieth centuries up until World War II, after which a social ...
Darling, Katherine +3 more
core +1 more source