Results 91 to 100 of about 4,841,906 (368)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Comparative Study of Leech-Derived Tryptase Inhibitor Genes in Four Medicinal Leech Species

Biology
Leeches are aquatic annelids of significant medicinal value, known to produce a variety of antithrombotic proteins. However, the extent of interspecies variation in these bioactive components remains poorly understood.
Mingkang Xiao, Fang Zhao, Tianyu Ye, Rui Ai, Lizhou Tang, Zichao Liu, Qingqian Zeng, Zuhao Huang, Gonghua Lin   +8 more
doaj   +1 more source

Influences of environmental and chemical parameters on the spatial growth patterns of four riverine cyprinid fishes

Knowledge and Management of Aquatic Ecosystems, 2015
Understanding intraspecific variability in fish somatic growth rates is important as growth is a key life history trait that plays a fundamental role in many biological and ecological processes.
Liu C., Chen Y., Britton J.R.
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A Solution to Chromium Toxicity? Unlocking the Multi-Faceted Role of Biochar

Plants
Chromium (Cr) toxicity poses a significant challenge to agricultural productivity, human health, and food security. Biochar (BC) is a versatile amendment employed to alleviate Cr toxicity.
Muhammad Umair Hassan, Qitao Su
doaj   +1 more source

Biological Invasion-Based Feature Selection Algorithm [PDF]

Jisuanji gongcheng
In nature, biological invasions have attracted attention because of their rapid development and significant ecological impacts. The introduction of populations to search for suitable habitats often has inherent logic, and communication between ...
ZHANG Jian, ZHANG Bo
doaj   +1 more source

Supplementary Data from Divergent Biological Response to Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer [PDF]

, 2023
Roland Seiler, Ewan A. Gibb, Natalie Q. Wang, Htoo Zarni Oo, Hung‐Ming Lam, Kim E. van Kessel, Charlotte S. Voskuilen, Brian Winters, Nicholas Erho, Mandeep Takhar, James W. Douglas, Funda Vakar‐Lopez, Simon J. Crabb, Bas W.G. van Rhijn, Elisabeth E. Fransen van de Putte, Ellen C. Zwarthoff, George N. Thalmann, Elai Davicioni, Joost L. Boormans, Marc Dall’Era, Michiel S. van der Heijden, Jonathan L. Wright, Peter C. Black   +22 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Land‐use change promotes avian diversity at the expense of species with unique traits

Ecology and Evolution, 2016
Land‐use change may alter both species diversity and species functional diversity patterns. To test the idea that species diversity and functional diversity changes respond in differing ways to land‐use changes, we characterize the form of the change in ...
Bernard W. T. Coetzee, Steven L. Chown
doaj   +1 more source

Biological Globalization: the other Grain Invasion [PDF]

Contemporary accounts of the history of globalization place the grain trade in a leading role. Narrowing price gaps for wheat in world markets serve as the key indicator of increasing market integration.
Alan L. Olmstead, Paul W. Rhode
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