Results 111 to 120 of about 405,367 (255)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Invasive Bank Vole (Myodes glareolus): A Model System for Studying Parasites and Ecoimmunology during a Biological Invasion. [PDF]

Animals (Basel), 2021
McManus A, Holland CV, Henttonen H, Stuart P.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Natura 2000 Areas, Road, Railway, Water, and Ecological Networks May Provide Pathways for Biological Invasion: A Country Scale Analysis. [PDF]

Plants (Basel), 2021
Szilassi P, Soóky A, Bátori Z, Hábenczyus AA, Frei K, Tölgyesi C, van Leeuwen B, Tobak Z, Csikós N.   +8 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Untargeted metabolomics reveals enhanced antioxidant capacity and key bioactive components of Gougunao No. 2 black tea

Frontiers in Nutrition
IntroductionCultivar background may influence antioxidant-related non-volatile metabolite composition of black tea even under identical manufacturing conditions, but the compositional basis and its relationship to assay-specific antioxidant readouts ...
Junjie Lu, Junjie Lu, Junjie Lu, Jiahao Ai, Jiahao Ai, Jiahao Ai, Cong Wang, Cong Wang, Cong Wang, Junfeng Jiang, Junfeng Jiang, Junfeng Jiang, Xinjie Zhou, Xinjie Zhou, Xinjie Zhou, Yongfa Guo, Yongfa Guo, Yongfa Guo, Zhuangzi Zhong, Zhuangzi Zhong, Zhuangzi Zhong, Jie Zhou, Jie Zhou, Jie Zhou, Yang Wu, Yang Wu, Yang Wu, Ding-kun Liu, Ding-kun Liu, Ding-kun Liu, Huimin Sun, Huimin Sun, Huimin Sun   +32 more
doaj   +1 more source

Breathing space: deoxygenation of aquatic environments can drive differential ecological impacts across biological invasion stages. [PDF]

Biol Invasions, 2021
Dickey JWE, Coughlan NE, Dick JTA, Médoc V, McCard M, Leavitt PR, Lacroix G, Fiorini S, Millot A, Cuthbert RN.   +9 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Light affects the resistance of native plant communities to Solidago canadensis with low invasion degrees

Global Ecology and Conservation
Light is an important factor for plant growth, and native plant communities are frequently invaded by alien plants to varying degrees. However, little is known about the effect of lighting on the resistance of native plant communities to alien plants ...
Rui Cheng, Jing-Fang Cai, Yu-Ting Guan, Li-Juan Yang, Yi-Luan Shen, Xiao-Li Yang, Da-Zhi Wang, Hong-Li Li, Fei-Hai Yu   +8 more
doaj   +1 more source