Results 121 to 130 of about 5,137,522 (260)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Climate change scenarios predict reduction in suitable habitats and range shifts for Ophiocordyceps sinensis (Berk.) in Hindu Kush Himalaya

Journal of Asia-Pacific Biodiversity
The Hindu Kush Himalayan region has seen a faster pace of anthropogenic climate warming than the global average during the last 50 years. Since the 1980s this region has been experiencing intense climatic events, notably elevation-dependent warming ...
Nadeem Salam, Harvinder Kaur Sidhu, Shaheeda Shaban, Zafar A. Reshi, Manzoor A. Shah   +4 more
doaj   +1 more source

The Invasive Bank Vole (Myodes glareolus): A Model System for Studying Parasites and Ecoimmunology during a Biological Invasion. [PDF]

Animals (Basel), 2021
McManus A, Holland CV, Henttonen H, Stuart P.   +3 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Natura 2000 Areas, Road, Railway, Water, and Ecological Networks May Provide Pathways for Biological Invasion: A Country Scale Analysis. [PDF]

Plants (Basel), 2021
Szilassi P, Soóky A, Bátori Z, Hábenczyus AA, Frei K, Tölgyesi C, van Leeuwen B, Tobak Z, Csikós N.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Breathing space: deoxygenation of aquatic environments can drive differential ecological impacts across biological invasion stages. [PDF]

Biol Invasions, 2021
Dickey JWE, Coughlan NE, Dick JTA, Médoc V, McCard M, Leavitt PR, Lacroix G, Fiorini S, Millot A, Cuthbert RN.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Untargeted metabolomics reveals enhanced antioxidant capacity and key bioactive components of Gougunao No. 2 black tea

Frontiers in Nutrition
IntroductionCultivar background may influence antioxidant-related non-volatile metabolite composition of black tea even under identical manufacturing conditions, but the compositional basis and its relationship to assay-specific antioxidant readouts ...
Junjie Lu, Junjie Lu, Junjie Lu, Jiahao Ai, Jiahao Ai, Jiahao Ai, Cong Wang, Cong Wang, Cong Wang, Junfeng Jiang, Junfeng Jiang, Junfeng Jiang, Xinjie Zhou, Xinjie Zhou, Xinjie Zhou, Yongfa Guo, Yongfa Guo, Yongfa Guo, Zhuangzi Zhong, Zhuangzi Zhong, Zhuangzi Zhong, Jie Zhou, Jie Zhou, Jie Zhou, Yang Wu, Yang Wu, Yang Wu, Ding-kun Liu, Ding-kun Liu, Ding-kun Liu, Huimin Sun, Huimin Sun, Huimin Sun   +32 more
doaj   +1 more source