Results 91 to 100 of about 768,999 (294)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Comparative Study of Leech-Derived Tryptase Inhibitor Genes in Four Medicinal Leech Species
BiologyLeeches are aquatic annelids of significant medicinal value, known to produce a variety of antithrombotic proteins. However, the extent of interspecies variation in these bioactive components remains poorly understood.
Mingkang Xiao +8 more
doaj +1 more source
Biological Invasion-Based Feature Selection Algorithm [PDF]
Jisuanji gongchengIn nature, biological invasions have attracted attention because of their rapid development and significant ecological impacts. The introduction of populations to search for suitable habitats often has inherent logic, and communication between ...
ZHANG Jian, ZHANG Bo
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
A Solution to Chromium Toxicity? Unlocking the Multi-Faceted Role of Biochar
PlantsChromium (Cr) toxicity poses a significant challenge to agricultural productivity, human health, and food security. Biochar (BC) is a versatile amendment employed to alleviate Cr toxicity.
Muhammad Umair Hassan, Qitao Su
doaj +1 more source
Land‐use change promotes avian diversity at the expense of species with unique traits
Ecology and Evolution, 2016 Land‐use change may alter both species diversity and species functional diversity patterns. To test the idea that species diversity and functional diversity changes respond in differing ways to land‐use changes, we characterize the form of the change in ...
Bernard W. T. Coetzee, Steven L. Chown
doaj +1 more source
, 2023 MSc lecture on urban biological invasions for Technische Universität Berlin, Germany.
openaire +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source