Results 61 to 70 of about 2,932,261 (286)

The Planteome database: an integrated resource for reference ontologies, plant genomics and phenomics

Nucleic Acids Res., 2017
The Planteome project (http://www.planteome.org) provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus
L. Cooper, A. Meier, Marie-Angélique Laporte, J. Elser, C. Mungall, Brandon T. Sinn, Dario Cavaliere, S. Carbon, Nathan A. Dunn, Barry Smith, Botong Qu, Justin Preece, E. Zhang, S. Todorovic, G. Gkoutos, J. Doonan, D. Stevenson, E. Arnaud, P. Jaiswal   +18 more
semanticscholar   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Application and Role of Ontologies in Biomedical Information Retrieval Systems

مجله انفورماتیک سلامت و زیست پزشکی, 2018
Introduction: Ontologies improve the quality of information retrieval (IR). Therefore, it is important to better know the process of ontology engineering and their application in IR.
Nader Alishan Karami, Mohsen Haji Zeinolabedini, Iraj Radad, Seyed Javad Ghazi-Mirsaeid   +3 more
doaj  

OnEX: Exploring changes in life science ontologies

BMC Bioinformatics, 2009
Background Numerous ontologies have recently been developed in life sciences to support a consistent annotation of biological objects, such as genes or proteins.
Gross Anika, Kirsten Toralf, Hartung Michael, Rahm Erhard   +3 more
doaj   +1 more source

A generic organ based ontology system, applied to vertebrate heart anatomy, development and physiology

Journal of Integrative Bioinformatics, 2011
We present a novel approach to modelling biological information using ontologies. The system interlinks three ontologies, comprising anatomical, developmental and taxonomical information, and includes instances of structures for different species.
Bertens Laura M.F., Slob Joris, Verbeek Fons J.   +2 more
doaj   +2 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Effective method for detecting error causes from incoherent biological ontologies

Mathematical Biosciences and Engineering, 2022
Computing the minimal axiom sets (MinAs) for an unsatisfiable class is an important task in incoherent ontology debugging. Ddebugging ontologies based on patterns (DOBP) is a pattern-based debugging method that uses a set of heuristic strategies based on
Yu Zhang, Haitao Wu , Jinfeng Gao, Yongtao Zhang, Ruxian Yao, Yuxiang Zhu   +5 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD. [PDF]

PLoS ONE, 2011
Chronic obstructive pulmonary disease (COPD) is a major public health problem with increasing prevalence worldwide. The primary aim of this study was to identify genes and gene ontologies associated with COPD severity.
Santiyagu M Savarimuthu Francis, Jill E Larsen, Sandra J Pavey, Edwina E Duhig, Belinda E Clarke, Rayleen V Bowman, Nick K Hayward, Kwun M Fong, Ian A Yang   +8 more
doaj   +1 more source