Results 51 to 60 of about 2,999,960 (264)

Isolation and Characterization of Articular Cartilage-Derived Cells Obtained by Arthroscopic Cartilage Biopsy from Non-Osteoarthritic Patients

Cells
Cartilage-derived migratory cells show great potential for autologous use in cartilage repair surgery. However, their collection through arthroscopic biopsy has not been previously reported in individuals without osteoarthritis.
Pedro Nogueira Giglio, Débora Levy, Phelipe Oliveira Favaron, Lucas da Ponte Melo, Cadiele Oliana Reichert, Fábio Alessandro de Freitas, Juliana Sampaio Silva, Walcy Paganelli Rosolia Teodoro, Sérgio Paulo Bydlowski, Marco Kawamura Demange   +9 more
doaj   +1 more source

Pharmacogenomics of Cardiovascular Pharmacology: Development of an Informatics System for Analysis of DNA Microarray Data With a Focus on Lipid Metabolism

Journal of Pharmacological Sciences, 2008
Genome-wide gene-expression data from DNA-microarray technology and molecular-network data from computational text-mining have led to a paradigm shift in biological research. However, interpretation of the huge amount of data is a bottleneck.
Yoshiyuki Takahara, Tomoko Kobayashi, Kazuhisa Takemoto, Tetsuya Adachi, Ken Osaki, Kozo Kawahara, Gozoh Tsujimoto   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Lipid peroxidation: Its effects on the formulation and use of pharmaceutical emulsions

Asian Journal of Pharmaceutical Sciences, 2017
Pharmaceutical delivery systems are developed to improve the physicochemical properties of therapeutic compounds. Emulsions are one of these drug delivering systems formulated using water, oils and lipids as main ingredients.
Ramona Khanum, Haema Thevanayagam
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

THEORETICAL AND PRACTICAL ISSUES OF BIOLOGICAL OXIDATION OF HYDROCARBONS BY MICROORGANISMS

Вавиловский журнал генетики и селекции, 2015
The paper deals with the theoretical issues of biological oxidation of oil hydrocarbons from alkanes to polycyclic aromatics. We analyze the mechanisms of biochemical processes of decomposition of oil components and provide an overview of data from ...
A. V. Bryanskaya, Yu. E. Uvarova, N. M. Slynko, E. A. Demidov, A. S. Rozanov, S. E. Peltek   +5 more
doaj  

Genetically dissecting the electron transport chain of a soil bacterium reveals a generalizable mechanism for biological phenazine-1-carboxylic acid oxidation.

PLoS Genetics
The capacity for bacterial extracellular electron transfer via secreted metabolites is widespread in natural, clinical, and industrial environments. Recently, we discovered the biological oxidation of phenazine-1-carboxylic acid (PCA), the first example ...
Lev M Z Tsypin, Scott H Saunders, Allen W Chen, Dianne K Newman   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Redox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesis

Journal of Translational Medicine
Background Protein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications in pancreatic cancer development remains poorly understood.
Chaochao Tan, Lichun Chen, Xiaoyu Guan, Wenyi Huang, Yinhong Feng, Ziyi Li, Ling Wu, Xiangping Huang, Qianhui Ouyang, Sixiang Liu, Ying Huang, Jiliang Hu   +11 more
doaj   +1 more source