Results 31 to 40 of about 3,543,672 (267)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Information and Life: Towards a Biological Understanding of Informational Phenomena
tripleC: Communication, Capitalism & Critique, 2008 This work explores a new understanding of informational phenomena based on the molecular organization of life. One of the central ideas is that the interrelationship among the recently framed fields of genomics, proteomics, and signaling science (crucial
Pedro C. Marijuán
doaj +1 more source
Special Issue “Application of Non-Linear Dynamics”
Applied Sciences, 2022 Nonlinear phenomena occur in engineering structures, biological systems, social processes, and in economics [...]
Roman Starosta, Jan Awrejcewicz
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
eLife, 2015 Motor proteins of the conserved kinesin-14 family have important roles in mitotic spindle organization and chromosome segregation. Previous studies have indicated that kinesin-14 motors are non-processive enzymes, working in the context of multi-motor ...
Christine Mieck +7 more
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Entropy, 2022 What information-processing strategies and general principles are sufficient to enable self-organized morphogenesis in embryogenesis and regeneration?
Santosh Manicka, Michael Levin
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
MoleculesLL-37 is the only member of the cathelicidin-type host defense peptide family in humans. It exhibits broad-spectrum bactericidal activity, which represents a distinctive advantage for future therapeutic targets.
Katarzyna Pastuszak +5 more
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Direct detection of a single photon by humans
Nature Communications, 2016 The detection limit of human vision has remained unclear. Using a quantum light source capable of generating single-photon states of light, authors here report that humans can perceive a single photon incidence on the eye with a probability above chance.
Jonathan N. Tinsley +6 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source