Results 41 to 50 of about 257,733 (262)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3

eLife, 2015
Motor proteins of the conserved kinesin-14 family have important roles in mitotic spindle organization and chromosome segregation. Previous studies have indicated that kinesin-14 motors are non-processive enzymes, working in the context of multi-motor ...
Christine Mieck, Maxim I Molodtsov, Katarzyna Drzewicka, Babet van der Vaart, Gabriele Litos, Gerald Schmauss, Alipasha Vaziri, Stefan Westermann   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Susceptibility of Legionella gormanii Membrane-Derived Phospholipids to the Peptide Action of Antimicrobial LL-37—Langmuir Monolayer Studies

Molecules
LL-37 is the only member of the cathelicidin-type host defense peptide family in humans. It exhibits broad-spectrum bactericidal activity, which represents a distinctive advantage for future therapeutic targets.
Katarzyna Pastuszak, Małgorzata Jurak, Bożena Kowalczyk, Jacek Tarasiuk, Agnieszka Ewa Wiącek, Marta Palusińska-Szysz   +5 more
doaj   +1 more source

Direct detection of a single photon by humans

Nature Communications, 2016
The detection limit of human vision has remained unclear. Using a quantum light source capable of generating single-photon states of light, authors here report that humans can perceive a single photon incidence on the eye with a probability above chance.
Jonathan N. Tinsley, Maxim I. Molodtsov, Robert Prevedel, David Wartmann, Jofre Espigulé-Pons, Mattias Lauwers, Alipasha Vaziri   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Thermodynamic Study on Biomimetic Legionella gormanii Bacterial Membranes

Molecules
The presented studies were aimed at determining the interactions in model membranes (Langmuir monolayers) created of phospholipids (PL) isolated from Legionella gormanii bacteria cultured with (PL + choline) or without (PL − choline) choline and to ...
Katarzyna Pastuszak, Marta Palusińska-Szysz, Agnieszka Ewa Wiącek, Małgorzata Jurak   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Quantum phenomena in biological systems

MOJ Biology and Medicine, 2020
The functioning of a biological systems, maintaining the dynamic stability of its homeostasis, is provided by regulatory systems. Traditionally, such systems include the nervous and humoral systems of regulation. The third regulatory system of the body, which provides communication in the body, distance interactions according to the "informational ...
Igor Orzhelskyi, Andrey Kuznetsov, Elena van Dijk   +2 more
openaire   +1 more source

An [Imperfect] Case for Dyadic Research in Pediatric Psychosocial Oncology

Pediatric Blood &Cancer, EarlyView.
Stephanie M. Nanos, Lindsay A. Jibb, Gary Rodin   +2 more
wiley   +1 more source