Results 21 to 30 of about 2,638,691 (365)
Estimating entropy production from waiting time distributions [PDF]
Phys. Rev. Lett. 127, 198101 (2021), 2021 Living systems operate far from thermal equilibrium by converting the chemical potential of ATP into mechanical work to achieve growth, replication or locomotion. Given time series observations of intra-, inter- or multicellular processes, a key challenge is to detect non-equilibrium behavior and quantify the rate of free energy consumption.
arxiv +1 more source
Improved bounds on entropy production in living systems [PDF]
Proc. Natl Acad. Sci. U.S.A. 118 (18), e2024300118 (2021), 2020 Living systems maintain or increase local order by working against the Second Law of Thermodynamics. Thermodynamic consistency is restored as they dissipate heat, thereby increasing the net entropy of their environment. Recently introduced estimators for the entropy production rate have provided major insights into the thermal efficiency of important ...
arxiv +1 more source
Zhongguo shuxue zazhi, 2023 Objective To investigate the trend of neutralizing antibody level in plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine.
Wenjuan GE +6 more
doaj +1 more source
Taking Biologics for Granted? Takings, Trade Secrets, and Off-Patent Biological Products [PDF]
, 2005 Biologics are complex medicines which are often genetically engineered, and which are sure to play an important role in curing some of humankind\u27s worst diseases. Not surprisingly, generic companies want a part of the biologic market. The FDA believes
Wasson, Andrew
core +3 more sources
Viruses, 2023 SARS-CoV-2 variants of concern (VOCs) show increasing transmissibility and infectivity and induce substantial injuries to human health and the ecology. Therefore, it is vital to understand the related features for controlling infection.
Yan Zeng +9 more
doaj +1 more source
Viruses, 2023 Outbreaks of hand, foot and mouth disease (HFMD) have occurred frequently in the Asian-Pacific region over the last two decades, caused mainly by the serotypes in Enterovirus A species.
Lie Fu +11 more
doaj +1 more source
Pharmacovigilance of Biosimilars [PDF]
, 2013 In lieu of an abstract, here is the article\u27s first paragraph: Biotech industry forms the backbone of the current pharmaceutical products. Seven out of top ten anticipated drugs of the industry in 2014 will be biologics [1].
Chablani, Lipika
core +2 more sources
Nonequilibrium Transport Induced by Biological Nanomachines [PDF]
Biophys. Rev. Lett. 17, 51 (2022), 2022 Biological nanomachines are nanometer-size macromolecular complexes that catalyze chemical reactions in the presence of substrate molecules. The catalytic functions carried out by such nanomachines in the cytoplasm, and biological membranes are essential for cellular metabolism and homeostasis. During catalytic reactions, enzymes undergo conformational
arxiv +1 more source
Advances in Next-Generation Coronavirus Vaccines in Response to Future Virus Evolution
Vaccines, 2022 Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread to more than 230 countries and territories worldwide since its outbreak in late 2019. In less than three years, infection by SARS-CoV-2 has
Lili Li +8 more
doaj +1 more source
Repeat-Dose Toxicity of Candidate Omicron COVID-19 Vaccine in Sprague-Dawley Rats
COVID, 2022 Due to a large number of mutations in the spike protein and immune escape, the Omicron variant (B.1.1.529) has become a predominant variant of concern (VOC) strain.
Yuxiu Zhao +18 more
doaj +1 more source