Results 21 to 30 of about 10,008,274 (374)

Comparative multiomics analysis of cell physiological state after culture in a basket bioreactor

Scientific Reports, 2022
Bioreactors are one of the most important, basic pieces of equipment in the biopharmaceutical industry. Understanding the effects of mechanical damage and other factors on the physiological state of cells during cell matrix culture is the basis for ...
Shouzhi Yu, Miaomiao Guo, Yadan Zhang, Cunpei Bo, Hongyang Liang, Hui Wang, Xiaoming Yang   +6 more
doaj   +1 more source

A multicenter phase Ⅲ clinical study of human prothrombin complex concentrate in treatment of hemophilia B

Zhongguo shuxue zazhi, 2022
Objective To evaluate the clinical efficacy and safety of one kind of human prothrombin complex concentrate in treatment of patients with hemophilia B.
Wei ZHANG, Yirun LIU, Yan WU, Xuanlin ZHONG, Qingshuang SONG, Shitao CHEN, Xueyun WANG, Caiping GUO, Zhan ZHANG, Yunjia ZHANG   +9 more
doaj   +1 more source

Development and Preliminary Application of a Droplet Digital PCR Assay for Quantifying the Oncolytic Herpes Simplex Virus Type 1 in the Clinical-Grade Production

Viruses, 2023
Oncolytic herpes simplex virus (oHSV) is a type of virus that selectively targets and kills cancer cells, leaving normal cells unharmed. Accurate viral titer is of great importance for the production and application of oHSV products. Droplet digital PCR (
Miaomiao Guo, Li Deng, Hongyang Liang, Yuyao Du, Wenrui Gao, Na Tian, Ying Bi, Jinghua Li, Tiancong Ma, Yuntao Zhang, Hui Wang   +10 more
doaj   +1 more source

Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China

BMC Medical Genomics, 2021
Background Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has changed since a large scale of outbreaks occurred in 1997.
Yuting Yu, Zhiyu Luo, Weiping Jin, Jianyi Mai, Shasha Qian, Jia Lu, Zhenni Wei, Shengli Meng, Zejun Wang, Xuhua Guan, Yeqing Tong, Shuo Shen   +11 more
doaj   +1 more source

Alum/CpG Adjuvanted Inactivated COVID-19 Vaccine with Protective Efficacy against SARS-CoV-2 and Variants

Vaccines, 2022
Since the beginning of the COVID-19 pandemic, numerous variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged, including five variants of concern (VOC) strains listed by the WHO: Alpha, Beta, Gamma, Delta and Omicron ...
Yuntao Zhang, Xiaotong Zheng, Wang Sheng, Hongyang Liang, Yuxiu Zhao, Xiujuan Zhu, Rong Yang, Yadan Zhang, Xiaofei Dong, Weidong Li, Fei Pei, Ling Ding, Zhen Chang, Li Deng, Guangying Yuan, Zhaona Yang, Di Zhu, Xiaoming Yang, Hui Wang   +18 more
doaj   +1 more source

Study on the change of neutralizing antibody level in plasma donors after a third shot of inactivated novel coronavirus vaccine

Zhongguo shuxue zazhi, 2023
Objective To investigate the trend of neutralizing antibody level in plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine.
Wenjuan GE, An ZHOU, Junying SHEN, Xiaoqing LI, Jie MA, Mengzhao ZHU, Changyong JIAN   +6 more
doaj   +1 more source

The efficiency of biological products’ use for winter wheat varieties in the Rostov region

Grain Economy of Russia, 2020
In the conditions of insufficient and unstable moisture in the Rostov Region, unilateral application of mineral fertilizers for winter wheat is not always justified due to a lack of moisture in the soil.
D. A. Repka, L. P. Beltyukov, Е. К. Kuvshinova, E. A. Potapov   +3 more
semanticscholar   +1 more source

Comparative Study on MNVT of OPV Type I and III Reference Products in Different Periods

Diseases, 2023
Widespread vaccination using the oral live attenuated polio vaccine (OPV) and Sabin strain inactivated vaccine (sIPV) have greatly reduced the incidence of polio worldwide.
Xiyan Wang, Ruirui Ren, Bo Ma, Jing Xie, Yan Ma, Hong Luo, Yu Guo, Ling Ding, Liang Zhang, Mengyuan Zhang, Tianlang Wang, Zhichao Shuang, Xiujuan Zhu   +12 more
doaj   +1 more source

Selection of sterilizing-grade filter for preparation of human coagulation factor Ⅷ/ von Willebrand factor complex

Zhongguo shuxue zazhi, 2023
Objective To screen the sterilizing-grade filters applicable for production of human coagulation factor Ⅷ/von Willebrand factor complex(FⅧ/VWF)and study the sterilization filtration process.
Quanjuan GUO, An ZHOU, Wenjie LIU, Yike XU, Wenqiang SHI, Chen CHEN, Changyong JIAN   +6 more
doaj   +1 more source

Taking Biologics for Granted? Takings, Trade Secrets, and Off-Patent Biological Products [PDF]

, 2005
Biologics are complex medicines which are often genetically engineered, and which are sure to play an important role in curing some of humankind\u27s worst diseases. Not surprisingly, generic companies want a part of the biologic market. The FDA believes
Bergman, Karl-Olof, Milberg, Per, Wikstroem, Linnea   +2 more
core   +3 more sources