Results 71 to 80 of about 1,240,733 (309)
Scientific ReportsRNA editing is an important post-transcriptional modification for gene regulation and protein diversity. Detecting these modifications, especially Differential Variants on RNA (DVRs), presents significant challenges due to interference from sequencing ...
Jun Sun, Chi Zhang, Xiuling Li
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
BIOLOGICAL PRODUCT - BIOINSECTICIDE
European Journal of Medical Genetics and Clinical BiologyIn this article Bacillus thuringiensis var.thuringiensis on the bacterial strain thuringiensis Uzviti М №1, data are presented on the research work on the study of the insecticidal properties being carried out at the same time on the experimental series of the biological drug bioinsecticid, which was first prepared in a laboratory ...
Pulotov F.S, Sayfiddinov K.F
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Raport privind controlul calitaţii microbiologice a produselor farmaceutice veterinare în anul 2014 / Report regarding the microbiological quality control of the veterinary pharmaceutical products during 2014 [PDF]
Medicamentul Veterinar, 2015 The microbiological contamination of pharmaceutical products could have major consequences on the physical – chemical characteristics, safety and efficiency of the medicinal products, on the out of specification products recall-associated costs and, very
Simona Sturzu +6 more
doaj
Deciphering the photolysis products and biological concerns of triclosan under UVC and UVA
, 2023 Liping Li +9 more
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source