Results 91 to 100 of about 3,178,330 (288)
Telangana Journal of PsychiatryArvid Carlsson’s discoveries transformed psychiatry by establishing a direct neurochemical basis for mental illness. By conclusively demonstrating dopamine as a neurotransmitter and elucidating its role in brain function, Carlsson laid the groundwork for
Samyadip Bardhan, Vivaswan Boorla
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Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?
Disease Models & Mechanisms, 2022 Steven J. Clapcote
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Psychiatry outside the framework of empiricism
Nigerian Postgraduate Medical Journal, 2017 Science is interested in whatever that is empirical and objective. Any claim that cannot be objectively demonstrated has no place in science, because the subject does not deviate from the role, which it has set out to play in the life of mankind ...
Celestine Okorome Mume
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, 1990 Much contemporary psychiatry has a physical conceptualisation of mental disorders, but the term ‘organic psychiatry’ has a narrower meaning. Lishman (1987) defined it as the “cognitive, behavioural and emotional consequences of cerebral disorder”, and ...
Tom Dening
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Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
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Enabling Precision Psychiatry through 'omics': From Biomarkers to Biological Pathways
, 2017 Enabling Precision Psychiatry through 'omics': From Biomarkers to Biological ...
Michael Berk (13060851) +1 more
core
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
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45 years German Society of Biological Psychiatry (DGBP). [PDF]
J Neural Transm (Vienna), 2023 Riederer P +6 more
europepmc +1 more source