Results 101 to 110 of about 3,829,242 (325)

How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?

Disease Models & Mechanisms, 2022
Steven J. Clapcote
doaj   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Erratum to "The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism" [Prog Neuro-Psychopharmacol Biol Psychiatry 33(2009) 1479-1483] [PDF]

, 2011
Lonsdorf T, Rück C, Bergström J, et al. Erratum to "The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism" [Prog Neuro-Psychopharmacol Biol Psychiatry 33(2009) 1479-1483].
Gerhard Andersson, Ruck, Christian,, Andersson, Gerhard, Lindefors, Nils,, Lonsdorf, Tina B,, Bergstrom, Jan,, Ohman, Arne,, Bergström, Jan, Christian Rück, Lindefors, Nils, Jan Bergström, Nils Lindefors, Lonsdorf, Tina, Rück, Christian, Schalling, Martin,, Martin Schalling, Arne Öhman, Öhman, Arne, Andersson, Gerhard,, Schalling, Martin, Tina B. Lonsdorf   +20 more
core   +1 more source

Biological research involving people with lived experience of childhood trauma: a trauma-informed approach

Frontiers in Psychology
In this Perspective, we highlight the growing need for trauma-informed practices as researchers increasingly work across disciplines to study the effects of childhood trauma.
Mica Komarnyckyj, Derek Clougher, Bethany Thompson   +2 more
doaj   +1 more source

The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the treatment of adolescent sexual offenders with paraphilic disorders

World Journal of Biological Psychiatry, 2015
The primary aim of these guidelines was to evaluate the role of pharmacological agents in the treatment of adolescents with paraphilic disorders who are also sexual offenders or at-risk of sexual offending.
F. Thibaut, J. Bradford, P. Briken, F. de la Barra, F. Hässler, P. Cosyns   +5 more
semanticscholar   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

From dopamine to the Nobel Prize: Arvid Carlsson and the foundations of neurobiology-based psychiatry

Telangana Journal of Psychiatry
Arvid Carlsson’s discoveries transformed psychiatry by establishing a direct neurochemical basis for mental illness. By conclusively demonstrating dopamine as a neurotransmitter and elucidating its role in brain function, Carlsson laid the groundwork for
Samyadip Bardhan, Vivaswan Boorla
doaj   +1 more source

Precision psychiatry roadmap: towards a biology-informed framework for mental disorders

Molecular Psychiatry
The current classification systems for mental disorders provide a uniform symptom-based language to describe and diagnose mental disorders. Clinicians use these classifications to communicate with their patients and colleagues, to treat patients, and ...
M. Kas, B. Penninx, G. Knudsen, Bruce Cuthbert, P. Falkai, G. Sachs, K. Ressler, Ewa Bałkowiec-Iskra, F. Butlen-Ducuing, M. Leboyer, Hugh M. Marston, J. Luthman, V. Mantua   +12 more
semanticscholar   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source