Results 81 to 90 of about 3,178,330 (288)

Deep brain stimulation in major depression: Plastic changes of 5-hydroxytryptamine neurons

, 2015
Refers to: Antidepressant-like Effects of Cortical Deep Brain Stimulation Coincide With Pro-neuroplastic Adaptations of Serotonin Systems. Biological Psychiatry 76(3): 203-212 (2014)Referred to by: Erratum.
Artigas, Francesc
core   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

The time of prenatal stress exposure differentially alter behaviors in male and female offspring

, 2011
The 10th World Congress of Biological Psychiatry (WFSBP 2011), Prague, Czech Republic, 29 May-2 June ...
Chen, M, McAlonan, G, Ao, L, Rudd, JA, Lu, G, Jiu, T, Li, Q   +6 more
core  

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Biological research involving people with lived experience of childhood trauma: a trauma-informed approach

Frontiers in Psychology
In this Perspective, we highlight the growing need for trauma-informed practices as researchers increasingly work across disciplines to study the effects of childhood trauma.
Mica Komarnyckyj, Derek Clougher, Bethany Thompson   +2 more
doaj   +1 more source

The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism

, 2009
Lonsdorf T, Rückert-Reed C, Bergström J, et al. The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism. Progress in Neuro-Psychopharmacology and Biological Psychiatry.
Andersson, Gerhard, Lindefors, Nils, Lonsdorf, Tina, Öhman, Arne, Schalling, Martin, Bergström, Jan, Rückert-Reed, Christian ; https://orcid.org/, Ruck, Christian,, Lindefors, Nils,, Lonsdorf, Tina B,, Bergstrom, Jan,, Schalling, M,, Ohman, A,, Ohman, Arne,, Bergstrom, J, Ruck, C, Schalling, Martin,, Andersson, Gerhard,, Lindefors, N,, Andersson, G,, Lonsdorf, TB, Gerhard Andersson, Christian Rück, Jan Bergström, Nils Lindefors, Tina B. Lonsdorf, Martin Schalling, Arne Öhman   +27 more
core   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

A Phenomenological Contribution to the Approach of Biological Psychiatry

, 2010
This article develops a phenomenological contribution to biological psychiatry. Grounded in the principles of transformation, heterogeneity, proportionality and particularity, a paradigm of phenomenological orientation allocates to biology a role ...
Guilherme P. Messas
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Decrease of Event Related Delta Oscillations in Euthymic Patients with Bipolar Disorder

, 2013
68th Annual Scientific Meeting of the Society-of-Biological-Psychiatry -- MAY 16-18, 2013 -- San Francisco, CA[No Abstract Available]Soc Biol ...
Başar, Erol, Atagün, Murat İlhan, Masali, Belinda, Guntekin, Bahar, Tulay, Elif   +4 more
core   +1 more source