Biological Psychiatry Sketched—Past, Present, and Future [PDF]
Jaak Panksepp
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In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
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Biological Psychiatry: Global Open Science-Supporting Open Science and Global Diversity in Research. [PDF]
Barch DM.
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The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders, Part III: Maintenance Treatment [PDF]
Heinz Grunze +5 more
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This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo +17 more
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Proof of Concept of the Contribution of the Interaction between Trait-like and State-like Effects in Identifying Individual-Specific Mechanisms of Action in Biological Psychiatry. [PDF]
Zilcha-Mano S +4 more
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Biological Psychiatry: A Practice in Search of a Science [PDF]
W. Joseph Wyatt, Donna M. Midkiff
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Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan +12 more
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A brief summary of the articles appearing in this issue of Biological Psychiatry [PDF]
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Károly Schaffer and his school: The birth of biological psychiatry in Hungary, 1890–1940 [PDF]
Brigitta Baran +4 more
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