Results 61 to 70 of about 3,684,448 (359)

Visual attention deficits in schizophrenia can arise from inhibitory dysfunction in thalamus or cortex [PDF]

, 2018
Schizophrenia is associated with diverse cognitive deficits, including disorders of attention-related oculomotor behavior. At the structural level, schizophrenia is associated with abnormal inhibitory control in the circuit linking cortex and thalamus ...
Barbas, Helen, Bullock, Daniel, John, Yohan J., Zikopoulos, Basilis   +3 more
core   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Meynert and the biological German psychiatry

Arquivos de Neuro-Psiquiatria, 2012
Theodor Hermann Meynert (1833-1892), a German-Austrian neuropathologist and anatomist, is known as one of the founders of the Brain Psychiatry. He was the most arduous defender of the bridge between psychological and neurophysiological events, both ...
Marleide da Mota Gomes, Eliasz Engelhardt   +1 more
doaj   +1 more source

Narrative psychiatry: Healing through storytelling

European Psychiatry, 2021
Introduction We all have the innate ability to tell our story and the way we do it can determine the impact that each problem has on our lives.
J. Gonçalves Cerejeira, C. Rivera Jiménez, I. Santos Carrasco, C. Capella, E. Rodríguez   +4 more
doaj   +1 more source

'The risks of playing it safe': a prospective longitudinal study of response to reward in the adolescent offspring of depressed parents [PDF]

, 2013
BACKGROUND Alterations in reward processing may represent an early vulnerability factor for the development of depressive disorder. Depression in adults is associated with reward hyposensitivity and diminished reward seeking may also be a feature of ...
A. Rawal, A. Thapar, F. Rice, Howell, S. Collishaw, Wechsler, Weissman   +6 more
core   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Translational significance of neurodevelopment underpinned ‘neurophysiological-cognitive’ biomarkers in schizophrenia

Indian Journal of Psychiatry
Biomarker research helps validate diagnostic entities that are otherwise based on pure clinical sense and prone to subjectivity bias. Biomarker research in the field of schizophrenia and psychoses dates back to more than a century. However, the focus on ‘
Sai Krishna Tikka
doaj   +1 more source

Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. [PDF]

, 2014
Trichotillomania is characterized by repetitive pulling out of one's own hair. Impaired response inhibition has been identified in patients with trichotillomania, along with gray matter density changes in distributed neural regions including frontal ...
Chamberlain, Samuel R., Derbyshire, Katie L., Grant, Jon E., Leppink, Eric W., Odlaug, Brian L.   +4 more
core   +3 more sources

Pre‐Diagnostic Features of Multiple Sclerosis in a Diverse UK Cohort: A Nested Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Many patients with Multiple Sclerosis (MS) experience nonspecific symptoms prior to diagnosis. This period—the 'MS prodrome'—has been described in socio‐economically homogeneous cohorts to date. It remains unclear to what extent events prior to an MS diagnosis differ according to social determinants of health. Methods We conducted a
Pooja Tank, Benjamin M. Jacobs, Jonathan Bestwick, Ruth Dobson   +3 more
wiley   +1 more source

The computational psychiatry of reward: Broken brains or misguided minds?

Frontiers in Psychology, 2015
Research into the biological basis of emotional and motivational disorders is in danger of riding roughshod over a patient-centred psychiatry and falling into the dualist errors of the past, i.e. by treating mind and brain as conceptually distinct.
Michael eMoutoussis, Giles eStory, Ray eDolan, Ray eDolan   +3 more
doaj   +1 more source