Results 141 to 150 of about 10,137,482 (392)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro

iScience
Summary: Mosquito borne flaviviruses such as dengue and Zika represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Vertebrate host responses to dengue and Zika infections include the processing and
Gaurav Shrivastava, Paola Carolina Valenzuela-Leon, Karina Botello, Eric Calvo   +3 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Cannabinoid overrides triggers of GABAergic plasticity in vestibular circuits and distorts the development of navigation

iScience
Summary: Early life exposure to cannabis can result in long-lasting deficits in spatial navigation. We ask if the development of this behavior is subject to early life activity of type I cannabinoid receptor (CB1R) in the vestibular nucleus.
Wei Shi, Kenneth Lap-Kei Wu, Mengliu Yang, Francisco Paulo De Nogueira Botelho, Oscar Wing-Ho Chua, Hui-Jing Hu, Ka-Pak Ng, Ulysses Tsz-Fung Lam, Kin-Wai Tam, Chun-Wai Ma, Daisy Kwok-Yan Shum, Ying-Shing Chan   +11 more
doaj   +1 more source

XX. Meaning in the Physical Sciences

, 1958
The twentieth century has seen two major revolutions in our theories of physics concerning nature, and these have made us change many of our concepts about the terms in which nature can be described.
Bloom, Robert L., Crapster, Basil L., Dunkelberger, Harold L., Glatfelter, Charles H., Mara, Richard T., Richardson, Norman E., Schubart, W. Richard   +6 more
core  

Psychology [PDF]

, 2014
Genetics and the biological sciences are the two contemporary scientific fields most readily called to mind in thinking about science and eugenics. Yet the history of another discipline, psychology, is enmeshed more intricately with eugenics than are the
Wilson, Robert A.
core  

THE BIOLOGICAL SECTION OF THE UKRAINIAN ACADEMY OF SCIENCES [PDF]

, 1943
Nikolai Grishko
openalex   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

3-Deazaguanosine inhibits SARS-CoV-2 viral replication and reduces the risk of COVID-19 pneumonia in hamster

iScience
Summary: The COVID-19 pandemic highlighted the serious threat that coronaviruses have on public health. Because coronavirus continuously undergoes cross-species transmission, additional therapeutic agents and targets are urgently needed.
Noriko Saito-Tarashima, Takaaki Koma, Naoto Hinotani, Keigo Yoshida, Moka Ogasa, Akiho Murai, Syuya Inoue, Tomoyuki Kondo, Naoya Doi, Koichi Tsuneyama, Masako Nomaguchi, Noriaki Minakawa   +11 more
doaj   +1 more source

International Union of Biological Sciences : Fellowships [PDF]

, 1947
James Hutton Memorial
openalex   +1 more source