Results 121 to 130 of about 14,620,972 (263)

Commensal human gut microbes produce species specific neuroactive compounds

iScience
Summary: The gut microbiota communicates with multiple organs through neuroactive molecules, but the specific compounds produced remain unclear. We investigated eight commensal gut species, Lactococcus lactis, Enterococcus faecalis, Blautia producta ...
Anna M. Tingler, Charulekha Packirisamy, Alyssa Gutierrez, Adelaide E. Horvath, Makenna Grozis, Sigmund J. Haidacher, Kathleen M. Hoch, Anthony M. Haag, Numan Oezguen, Kristen A. Engevik, Amy C. Engevik, Thomas D. Horvath, Melinda A. Engevik   +12 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Biological Sciences Newsletter, Fall/Winter 2016

, 2016
This is the alumni newsletter for the Dept.

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Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation

iScience
Summary: Lymphatic vessels are required for the clearance of excess fluid and immune cells from inflamed tissue, making the regulation of lymphangiogenesis an important area of research.
Daisuke Katoh, Yoshiyuki Senga, Kento Mizutani, Kazuaki Maruyama, Daishi Yamakawa, Tadashi Yamamuro, Michiaki Hiroe, Keiichi Yamanaka, Akihiro Sudo, Naoyuki Katayama, Toshimichi Yoshida, Kyoko Imanaka-Yoshida   +11 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Referees for Volume 37, n. 1 of the Acta Scientiarium. Biological Sciences, 2015

, 2015
The Editorial Board of Acta Scientiarum. Biological Sciences would like to thank the referees listed below for their critical appreciation of articles submitted for Volume 37, n. 1 (2015).
Biological Sciences, Acta Scientiarum.; Referees
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Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

American Institute of Biological Sciences

, 2005
An important organization for biologists and science educators, the American Institute of Biological Sciences (AIBS) "was established as a national umbrella organization for the biological sciences in 1947 by 11 scientific societies as part of the ...

core  

Dishevelled localization and function are differentially regulated by structurally distinct sterols

iScience
Summary: The Dishevelled (DVL) protein family forms supramolecular protein and lipid complexes at the cytoplasmic interface of the plasma membrane to regulate tissue patterning, proliferation, cell polarity, and DVL-dependent signaling, such as Wnt/β ...
Sonali Sengupta, Jazmine D.W. Yaeger, Maycie M. Schultz, Danielle G. May, Kyle J. Roux, Kevin R. Francis   +5 more
doaj   +1 more source