Results 101 to 110 of about 14,620,972 (263)

Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

iScience
Summary: Non-invasive assessment of fibrogenic activity, rather than fibrotic scars, could significantly improve the management of fibrotic diseases and the development of anti-fibrotic drugs.
Olivia Wegrzyniak, Francesco Lechi, Bogdan Mitran, Pierre Cheung, Athanasios Bitzios, Jonas Persson, John Löfblom, Helena Nordström, Jonas Eriksson, Fredrik Y. Frejd, Olle Korsgren, Bo Zhang, Olof Eriksson   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Biological Sciences Newsletter, Spring 2008

, 2008
This is the alumni newsletter for the Dept.

core  

The upper limit of protein thermostability [PDF]

, 1989
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1989.Includes bibliographical references (leaves 143-158).by David B.
Volkin, David B. (David Bernard)
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Biological Sciences Newsletter, Fall/Winter 2018

, 2018
This is the alumni newsletter for the Dept.

core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Biological Sciences Newsletter, Spring/Summer 2017

, 2017
This is the alumni newsletter for the Dept.

core  

A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice

iScience
Summary: Dengue virus (DENV) is a mosquito-transmitted flavivirus; there are four serotypes (DENV1-4) that co-circulate globally. Primary infection causes self-limiting febrile illness, but secondary infection by a heterologous serotype can predispose to
Margarette C. Mariano, Helen S. Jung, Olivia Vergnolle, Keith Haskell, Lamount R. Evanson, Gregory Quevedo, Julia C. Frei, Karen Tong, Larissa B. Thackray, Michael S. Diamond, Jonathan R. Lai   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source