Results 11 to 20 of about 8,122,717 (304)
iScience, 2022 Summary: Aortic endothelial cell dysfunction is an early trigger of atherosclerosis, the major cause of the cardiovascular disease (CVD). Nanomedicines targeting vascular endothelium and lesions hold great promise as therapeutic solutions to vascular ...
Yuxiang Zhou +9 more
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Influence of data sampling methods on the representation of neural spiking activity in vivo
iScience, 2022 Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden +2 more
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The RBPMSCreERT2-tdTomato mouse line for studying retinal and vascular relevant diseases
iScience, 2023 Summary: RNA-binding protein with multiple splicing (RBPMS) plays a crucial role in cardiac mesoderm specification and cardiovascular development, as well as being a typical marker for whole retinal ganglion cells (RGCs).
Guilan Li +6 more
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Top-down reconfiguration of SMA cortical connectivity during action preparation
iScience, 2023 Summary: The Bereitschaftspotential (BP), a scalp potential recorded in humans during action preparation, is characterized by a slow amplitude increase over fronto-central regions as action execution approaches.
Valentina Bianco +4 more
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Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
iScience, 2021 Summary: Spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. The cultures are maintained under different conditions, with possible confounding results. We performed an in-depth analysis of the
Niklas Handin +10 more
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iScience, 2023 Summary: Coordinated temporal control of gene expression is essential for physiological homeostasis, especially during metabolic transitions. However, the interplay between chromatin architectural proteins and metabolism in regulating transcription is ...
Devashish Sen +10 more
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Whole-brain optical access in a small adult vertebrate with two- and three-photon microscopy
iScience, 2022 Summary: Although optical microscopy has allowed scientists to study the entire brain in early developmental stages, access to the brains of live, adult vertebrates has been limited.
Najva Akbari +5 more
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The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods
iScience, 2020 Summary: The reproducibility crisis is a multifaceted problem involving ingrained practices within the scientific community. Fortunately, some causes are addressed by the author's adherence to rigor and reproducibility criteria, implemented via ...
Joe Menke +4 more
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Evidence for a two-step model of social group influence
iScience, 2022 Summary: Social group influence plays an important role in societally relevant phenomena such as rioting and mass panic. One way through which groups influence individuals is by directing their gaze. Evidence that gaze following increases with group size
Emiel Cracco +7 more
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The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans
iScience, 2022 Summary: Non-human primates (NHP) are widely used for the pre-clinical assessment of antiretrovirals (ARVs) for HIV treatment and prevention. However, the utility of these models is questionable given the differences in ARV pharmacology between humans ...
Carolina Herrera +12 more
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