Results 91 to 100 of about 430,909 (261)

Cheminformatics Research at the Unilever Centre for Molecular Science Informatics Cambridge. [PDF]

, 2015
The Centre for Molecular Informatics, formerly Unilever Centre for Molecular Science Informatics (UCMSI), at the University of Cambridge is a world-leading driving force in the field of cheminformatics.

core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

High-throughput assessment of vocal modulation following chemogenetic inhibition in songbirds

iScience
Summary: Chemogenetic tools that enable reversible manipulation of neuronal activity are essential for studying the neural bases of behavior, yet their application in songbirds remains limited.
Chenyi Song, Mizuki Fujibayashi, Kentaro Abe   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors

iScience
Summary: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood and adolescence. The availability of appropriate and well-characterized preclinical models for RMS is limited, posing a challenge for investigating the molecular ...
Yuxiang Hu, Ziqi He, Shuangai Liu, Wenwen Ying, Yifan Chen, Manli Zhao, Min He, Xuan Wu, Yinbing Tang, Weizhong Gu, Meidan Ying, Jinhu Wang, Ting Tao   +12 more
doaj   +1 more source

Research collaboration between China and Denmark for development of systemic approaches to agro-ecological pest management without pesticides with focus on vegetable, fruit and berry crops. Proceedings and recommendations from two network workshops [PDF]

, 2013
This report is the result of a network project which was established to discuss the potential for collaboration on development of systemic approaches to pest management without pesticides between Chinese and Danish researchers.
Andreasen, Lise, Eilenberg, Jørgen, Enkegaard, Annie, Guo, Yanbin, Halberg, Niels, Korsgaard, Maren, Langer, Vibeke, Liu, Yunhui, Munk, Lisa, Qiao, Yuhui, Ravnskov, Sabine, Sigsgaard, Lene, Steenberg, Tove, Wang, Jianwu, Wu, Wenliang, Zhang, Long, Zhu, Zengrong   +16 more
core  

Evaluating a Department’s Research: Testing the Leiden Methodology in Business and Management [PDF]

, 2013
The Leiden methodology (LM), also sometimes called the “crown indicator”, is a quantitative method for evaluating the research quality of a research group or academic department based on the citations received by the group in comparison to averages for ...
Abramo, Aksnes, Bornmann, Bornmann, Evangelia A.E.C.G. Lipitakis, Horrobin, John Mingers, Leydesdorff, Leydesdorff, Leydesdorff, Lundberg, Mahdi, Meho, Mingers, Mingers, Mingers, Moed, Moed, Moed, Moed, Moxham, Nederhof, Nederhof, Opthof, Rinia, Schubert, Todeschini, Van Leeuwen, van Raan, van Raan, van Raan, van Raan, van Raan, van Raan, Van Veller, Walters, Waltman, Waltman   +37 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

An update on the synthesis and reactivity of spiro-fused β-lactams [PDF]

, 2018
Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic beta-lactams, representing an important beta-lactam subclass, have recently attracted considerable interest with respect to new synthetic ...
D'hooghe, Matthias, Dao Thi, Hang
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source