Results 31 to 40 of about 743,637 (245)

Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER

iScience, 2023
Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee, Sergey Tumanov, Jason W.H. Wong, Roland Stocker, Joshua W.K. Ho   +4 more
doaj  

Physical and chemical mechanisms of tissue optical clearing

iScience, 2021
Summary: Advanced optical methods combined with various probes pave the way toward molecular imaging within living cells. However, major challenges are associated with the need to enhance the imaging resolution even further to the subcellular level for ...
Tingting Yu, Jingtan Zhu, Dongyu Li, Dan Zhu   +3 more
doaj  

Conceptualizing experimental controls using the potential outcomes framework [PDF]

arXiv, 2021
The goal of a well-controlled study is to remove unwanted variation when estimating the causal effect of the intervention of interest. Experiments conducted in the basic sciences frequently achieve this goal using experimental controls, such as "negative" and "positive" controls, which are measurements designed to detect systematic sources of unwanted ...
arxiv  

Biocomplexity: A pluralist research strategy is necessary for a mechanistic explanation of the "live" state [PDF]

, 2002
The biological sciences study (bio) complex living systems. Research directed at the mechanistic explanation of the "live" state truly requires a pluralist research program, i.e. BioComplexity research.
Boogerd, F. C., Bruggeman, F. J., Westerhoff, H. V.   +2 more
core   +1 more source

Molecular insights into the modulation of the 5HT2A receptor by serotonin, psilocin, and the G protein subunit Gqα

FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.
We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl, Ali Asghar Hakami Zanjani, Himanshu Khandelia   +2 more
wiley   +1 more source

Acoustic camera system for measuring ultrasound communication in mice

iScience, 2022
Summary: To investigate biological mechanisms underlying social behaviors and their deficits, social communication via ultrasonic vocalizations (USVs) in mice has received considerable attention as a powerful experimental model.
Jumpei Matsumoto, Kouta Kanno, Masahiro Kato, Hiroshi Nishimaru, Tsuyoshi Setogawa, Choijiljav Chinzorig, Tomohiro Shibata, Hisao Nishijo   +7 more
doaj  

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

Biological nanopores for single-molecule sensing

iScience, 2022
Summary: Evolution has found countless ways to transport material across cells and cellular compartments separated by membranes. Protein assemblies are the cornerstone for the formation of channels and pores that enable this regulated passage of ...
Simon Finn Mayer, Chan Cao, Matteo Dal Peraro   +2 more
doaj  

Using Full-text Content of Academic Articles to Build a Methodology Taxonomy of Information Science in China [PDF]

arXiv, 2021
Research on the construction of traditional information science methodology taxonomy is mostly conducted manually. From the limited corpus, researchers have attempted to summarize some of the research methodology entities into several abstract levels (generally three levels); however, they have been unable to provide a more granular hierarchy. Moreover,
arxiv  

Organic phosphorus in the terrestrial environment: a perspective on the state of the art and future priorities [PDF]

, 2017
Background The dynamics of phosphorus (P) in the environment is important for regulating nutrient cycles in natural and managed ecosystems and an integral part in assessing biological resilience against environmental change.
Almeida, D. S., Almås, Å. R., Audette, Y., Bertrand, I., Beyhaut, E., Blackwell, M. S. A., Boitt, G., Bol, R., Bradshaw, N., Brearley, C. A., Bruulsema, T. W., Cabugao, K. G., Celi, L., Ciais, P., Condron, L. M., Cotner, J. B., Cozzolino, V., Darch, T., de Menezes, A. B., Dodd, R. J., Dunfield, K., Duran, P. C., Engl, C., Feng, G., Fraser, T., Frazão, J. J., Gama-Rodrigues, A. C., Garland, G., George, T. S., Giesler, R., Giles, C. D., Goll, D. S., González Jiménez, J. L., Graca, J., Granger, S. J., Hallama, M., Harrison, A. F., Haygarth, P. M., Heuck, C., Hou, E. Q., Jaisi, D., Johnes, P. J., Kaiser, K., Kjær, H. A., Klumpp, E., Krueger, J., Lamb, A. L., Lang, F., Lumsdon, D. G., Macintosh, K. A., Mackay, E. B., McGrath, J., McIntyre, C., McLaren, T., Menezes-Blackburn, D., Mezeli, M. M., Missong, A., Mooshammer, M., Mora, M. L., Mészáros, E., Neal, A. L., Negrón, C. P., Nelson, L. A., Pfahler, V., Plassard, C., Poblete-Grant, P., Randall, M., Richardson, A. E., Rosling, A., Seguel, A., Seth, K., Shand, C. A., Smith, A. C., Smits, M. M., Sobarzo, J. A., Spohn, M., Stutter, M. I., Tamburini, F., Tawaraya, K., Tibbett, Mark, Voroney, P., Wallander, H., Wang, L., Wasaki, J., Wearing, C., Zhang, H.   +85 more
core   +11 more sources