Results 111 to 120 of about 1,333,897 (299)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Saliva proteomics updates in biomedicine

Journal of Biological Research - Thessaloniki, 2019
In the years of personalized (or precision) medicine the ‘omics’ methodologies in biomedical sciences—genomics, transcriptomics, proteomics and metabolomics—are helping researchers to detect quantifiable biological characteristics, or biomarkers, that ...
Katerina R. Katsani, Dimitra Sakellari
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Focused Ion Beam in the Study of Biomaterials and Biological Matter

Advances in Materials Science and Engineering, 2012
The application of focused ion beam (FIB) techniques in the life sciences has progressed by leaps and bounds over the past decade. A once dedicated ion beam instrument, the focused ion beam today is generally coupled with a plethora of complementary ...
Kathryn Grandfield, Håkan Engqvist
doaj   +1 more source

Initial training of biological sciences teachers: living the interactive methodology as teaching tools

, 2010
The present paper, developed with a group of second period of Biology Degree, had as main objective analyze our experience in the utilization of interactive methodology as didactic tool. Questionnaires and interviews were used with students in the process of collecting data; besides participant observation.
Araújo, Monica Lopes Folena, de Oliveira, Maria Marly, de França, Tereza Luiza   +2 more
openaire   +1 more source

Integrating bones and biomes: bringing biological science education to elementary school communities through a tangible learning tool

Journal of Microbiology & Biology Education
ABSTRACT Biology education in U.S. elementary schools faces challenges, including declining science proficiency and disparities among minority students. Limited resources, outdated materials, and a shortage of qualified educators hinder efforts to deliver engaging and equitable biology instruction.
Phillip R. Myer, Jennie L. Zambito Ivey
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Du déterminisme biologique au déterminisme social

Socio, 2016
Historical semantics, while being opposed to the idea of linear progress, does enable us to show that notions of biological determinism and social determinism were broadly conceived as being complementary.
Marc Joly
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Accurate and Efficient Mapping of the Cross-Linked microRNA-mRNA Duplex Reads

iScience, 2019
Summary: MicroRNA (miRNA) trans-regulates the stability of many mRNAs and controls their expression levels. Reconstruction of the miRNA-mRNA interactome is key to the understanding of the miRNA regulatory network and related biological processes. However,
Cuncong Zhong, Shaojie Zhang
doaj   +1 more source