Results 101 to 110 of about 510,635 (307)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Molecular Tools and Approaches for Optogenetics [PDF]

, 2012
The mammalian brain poses a formidable challenge to the study and treatment of neuropsychiatric diseases, owing to the complex interaction of genetic, epigenetic, and circuit-level mechanisms underlying pathogenesis.
Mei, Yuan, Zhang, Feng
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Pipettes and Pipelines: The Weapons of Omics Sciences for a New Age of Clinical Studies

Current Issues in Molecular Biology
The omics sciences represent a revolution for clinical studies, offering integrative approaches to analyzing biological data with unprecedented depth. From the discovery of the double-helix structure of DNA to the CRISPR-Cas9 gene editing tool, passing ...
Ícaro S. Lopes, Eduardo R. Fukutani, Tiago F. Mota, Bruno B. Andrade, Mariana Araújo-Pereira, Artur T. L. Queiroz   +5 more
doaj   +1 more source

The Bacterial Type III Secretion System as a Broadly Applied Protein Delivery Tool in Biological Sciences

Microorganisms
The type III secretion system (T3SS) is a nano-machine that allows Gram-negative bacteria to alter eukaryotic host biology by directly delivering effector proteins from the bacterial cytoplasm. Protein delivery based on the bacterial T3SS has been widely used in research in biology. This review explores recent advancements in the structure and function
Liyu Jia, Lihua Zhu
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Talk, tools, and tensions: observing biological talk over time [PDF]

, 2010
The goal of this study is to explore new tools for analyzing scientific sense making in out-of-school settings. Although such measures are now common in science classroom research, dialogically-based methodological approaches are relatively new to ...
Wheaton, Mele, Brandt, Carol, Ash, Doris, Loomis, Molly, Crain, Rhiannon, Bennett, Christine   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The DBCLS BioHackathon: standardization and interoperability for bioinformatics web services and workflows. The DBCLS BioHackathon Consortium* [PDF]

, 2010
Web services have become a key technology for bioinformatics, since life science databases are globally decentralized and the exponential increase in the amount of available data demands for efficient systems without the need to transfer entire databases
Kuhn, Michael, Nakamura, Hiroyuki, Yamamoto, Yasunori, Gutteridge Alex, Bonnal, Raoul JP, Kibukawa Eri, Kiyoshi Asai, Prins, Pjotr, Groscurth Andreas, Stuart Owen, Nakao, M., Sugawara Hideaki, Kerhornou Arnaud, Ono Keiichiro, Jan C Bryne, Wilkinson, Mark D, Arakawa, K., Reisinger, Florian, Zmasek Christian M, Heikki Lehvaslaiho, Lapp, Hilmar, Mitsuteru Nakao, Aerts Jan, Toshiaki Katayama, Kiyoko F Aoki-Kinoshita, Oswaldo Trelles, York William, Prins, J.C.P., Kawashima, Shuichi, Jan Aerts, Salwinski Lukasz, Kibukawa, Eri, Takagi, Toshihisa, Load Hendrix Barboza, Lukasz Salwinski, Kawas, Edward A, Fernández, José M, Yamamoto Yasunori, Lehvaslaiho Heikki, Nobata, Chikashi, Katayama, T., Shuichi Kawashima, Nobata Chikashi, Pocock Matthew, Bruskiewich, Richard, Paul MK Gordon, Michael Kuhn, William York, Jose M Fernendez, Hideaki Sugawara, Senger Martin, Pafilis Evangelos, Okamoto Shinobu, Standley Daron M, Funahashi, Akira, Vos, Rutger A, Kawas Edward A, Tamotsu Noguchi, Christian M Zmasek, Goto, Naohisa, Pafilis, Evangelos, Sugawara, Hideaki, Asai, Kiyoshi, Tashiro Toshiyuki, Groscurth, Andreas, Bonnal Raoul JP, Yamaguchi, Atsuko, Bruskiewich Richard, Ranzinger, René, Nishizawa Tatsuya, Lehvaslaiho, Heikki, Kawashima Shuichi, Wilkinson Mark D, Nakamura, Yasukazu, Standley, Daron M, Yasunori Yamamoto, Aranda, Bruno, Nakamura Hiroyuki, Yasumasa Shigemoto, Owen Stuart, Toshihisa Takagi, Schreiber Mark, Reisinger Florian, Thomas M Oinn, Martin Senger, Arakawa Kazuharu, Gutteridge, Alex, Atsuko Yamaguchi, Bruno Aranda, Raoul JP Bonnal, Shigemoto Yasumasa, Senger, Martin, Shinobu Okamoto, Katayama Toshiaki, Eri Kibukawa, Aerts, Jan, Aoki-Kinoshita Kiyoko F, Oinn, Thomas M, Pocock, Matthew, Richard Bruskiewich, Edward A Kawas, Gordon Paul MK, Andreas Groscurth, Tashiro, Toshiyuki, Trelles, Oswaldo, Mark D Wilkinson, Kinjo Akira R, Akira R Kinjo, Hong-Woo Chun, Gordon, Paul MK, Chun, Hong-Woo, Hiroyuki Nakamura, Hilmar Lapp, Prins Pjotr, Ono, Keiichiro, Nishizawa, Tatsuya, Nakamura Yasukazu, Asai Kiyoshi, Noguchi Tamotsu, Pjotr Prins, Nakao, Mitsuteru, Salwinski, Lukasz, Ranzinger René, Kazuharu Arakawa, Barboza, Lord, Aranda Bruno, Alex Gutteridge, Florian Reisinger, Akira Funahashi, Daron M Standley, York, William, Zmasek, Christian M, Trelles Oswaldo, Kinjo, Akira R, Okamoto, Shinobu, Vos Rutger A, Shigemoto, Yasumasa, Arnaud Kerhornou, Yasukazu Nakamura, Barboza Lord, Owen, Stuart, Keiichiro Ono, Bryne Jan C, Aoki-Kinoshita, Kiyoko F, Evangelos Pafilis, Oinn Thomas M, Naohisa Goto, Fernández José M, Funahashi Akira, Bryne, Jan C, Nakao Mitsuteru, Tatsuya Nishizawa, Noguchi, Tamotsu, Richard Holland, Rutger A Vos, Kerhornou, Arnaud, Kano, Yoshinobu, Takagi Toshihisa, Chikashi Nobata, Holland, Richard, Goto Naohisa, Mark Schreiber, Kano Yoshinobu, Rene Ranzinger, Arakawa, Kazuharu, Kuhn Michael, Lapp Hilmar, Toshiyuki Tashiro, Schreiber, Mark, Yamaguchi Atsuko, Holland Richard, Chun Hong-Woo, Yoshinobu Kano, Matthew Pocock, Katayama, Toshiaki   +174 more
core   +1 more source