Results 101 to 110 of about 507,580 (307)

The Bacterial Type III Secretion System as a Broadly Applied Protein Delivery Tool in Biological Sciences

Microorganisms
The type III secretion system (T3SS) is a nano-machine that allows Gram-negative bacteria to alter eukaryotic host biology by directly delivering effector proteins from the bacterial cytoplasm. Protein delivery based on the bacterial T3SS has been widely used in research in biology. This review explores recent advancements in the structure and function
Liyu Jia, Lihua Zhu
openaire   +3 more sources

Novel systems biology methods for the analysis, optimization, and visualization of kinetic and genome-scale stoichiometric models

, 2022
Genetic and metabolic engineering has made it possible to use microbial organisms as systems that can be engineered for various applications such as bio-product generation and bioremediation.
Hari, Archana
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

The DBCLS BioHackathon: standardization and interoperability for bioinformatics web services and workflows. The DBCLS BioHackathon Consortium* [PDF]

, 2010
Web services have become a key technology for bioinformatics, since life science databases are globally decentralized and the exponential increase in the amount of available data demands for efficient systems without the need to transfer entire databases
Kuhn, Michael, Nakamura, Hiroyuki, Yamamoto, Yasunori, Gutteridge Alex, Bonnal, Raoul JP, Kibukawa Eri, Kiyoshi Asai, Prins, Pjotr, Groscurth Andreas, Stuart Owen, Nakao, M., Sugawara Hideaki, Kerhornou Arnaud, Ono Keiichiro, Jan C Bryne, Wilkinson, Mark D, Arakawa, K., Reisinger, Florian, Zmasek Christian M, Heikki Lehvaslaiho, Lapp, Hilmar, Mitsuteru Nakao, Aerts Jan, Toshiaki Katayama, Kiyoko F Aoki-Kinoshita, Oswaldo Trelles, York William, Prins, J.C.P., Kawashima, Shuichi, Jan Aerts, Salwinski Lukasz, Kibukawa, Eri, Takagi, Toshihisa, Load Hendrix Barboza, Lukasz Salwinski, Kawas, Edward A, Fernández, José M, Yamamoto Yasunori, Lehvaslaiho Heikki, Nobata, Chikashi, Katayama, T., Shuichi Kawashima, Nobata Chikashi, Pocock Matthew, Bruskiewich, Richard, Paul MK Gordon, Michael Kuhn, William York, Jose M Fernendez, Hideaki Sugawara, Senger Martin, Pafilis Evangelos, Okamoto Shinobu, Standley Daron M, Funahashi, Akira, Vos, Rutger A, Kawas Edward A, Tamotsu Noguchi, Christian M Zmasek, Goto, Naohisa, Pafilis, Evangelos, Sugawara, Hideaki, Asai, Kiyoshi, Tashiro Toshiyuki, Groscurth, Andreas, Bonnal Raoul JP, Yamaguchi, Atsuko, Bruskiewich Richard, Ranzinger, René, Nishizawa Tatsuya, Lehvaslaiho, Heikki, Kawashima Shuichi, Wilkinson Mark D, Nakamura, Yasukazu, Standley, Daron M, Yasunori Yamamoto, Aranda, Bruno, Nakamura Hiroyuki, Yasumasa Shigemoto, Owen Stuart, Toshihisa Takagi, Schreiber Mark, Reisinger Florian, Thomas M Oinn, Martin Senger, Arakawa Kazuharu, Gutteridge, Alex, Atsuko Yamaguchi, Bruno Aranda, Raoul JP Bonnal, Shigemoto Yasumasa, Senger, Martin, Shinobu Okamoto, Katayama Toshiaki, Eri Kibukawa, Aerts, Jan, Aoki-Kinoshita Kiyoko F, Oinn, Thomas M, Pocock, Matthew, Richard Bruskiewich, Edward A Kawas, Gordon Paul MK, Andreas Groscurth, Tashiro, Toshiyuki, Trelles, Oswaldo, Mark D Wilkinson, Kinjo Akira R, Akira R Kinjo, Hong-Woo Chun, Gordon, Paul MK, Chun, Hong-Woo, Hiroyuki Nakamura, Hilmar Lapp, Prins Pjotr, Ono, Keiichiro, Nishizawa, Tatsuya, Nakamura Yasukazu, Asai Kiyoshi, Noguchi Tamotsu, Pjotr Prins, Nakao, Mitsuteru, Salwinski, Lukasz, Ranzinger René, Kazuharu Arakawa, Barboza, Lord, Aranda Bruno, Alex Gutteridge, Florian Reisinger, Akira Funahashi, Daron M Standley, York, William, Zmasek, Christian M, Trelles Oswaldo, Kinjo, Akira R, Okamoto, Shinobu, Vos Rutger A, Shigemoto, Yasumasa, Arnaud Kerhornou, Yasukazu Nakamura, Barboza Lord, Owen, Stuart, Keiichiro Ono, Bryne Jan C, Aoki-Kinoshita, Kiyoko F, Evangelos Pafilis, Oinn Thomas M, Naohisa Goto, Fernández José M, Funahashi Akira, Bryne, Jan C, Nakao Mitsuteru, Tatsuya Nishizawa, Noguchi, Tamotsu, Richard Holland, Rutger A Vos, Kerhornou, Arnaud, Kano, Yoshinobu, Takagi Toshihisa, Chikashi Nobata, Holland, Richard, Goto Naohisa, Mark Schreiber, Kano Yoshinobu, Rene Ranzinger, Arakawa, Kazuharu, Kuhn Michael, Lapp Hilmar, Toshiyuki Tashiro, Schreiber, Mark, Yamaguchi Atsuko, Holland Richard, Chun Hong-Woo, Yoshinobu Kano, Matthew Pocock, Katayama, Toshiaki   +174 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Estimating trauma prevalence from incomplete human skeletal remains

Scientific Reports
Traumatic lesions on human skeletal remains are widely used for reconstructing past accidents or violent encounters and for comparing trauma prevalence across samples over time and space.
Judith Beier, Matteo Santon, Hannes Rathmann   +2 more
doaj   +1 more source

Hook tool manufacture in New Caledonian crows : behavioural variation and the influence of raw materials

, 2015
Funding: BBSRC grants BB/G023913/1 and BB/G023913/2Background: New Caledonian crows use a range of foraging tools, and are the only non-human species known to craft hooks.
Klump, B., Rutz, Christian, St Clair, James, Sugasawa, S., Klump, Barbara Christina, St Clair, J., Sugasawa, Shoko, Rutz, C.   +7 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Saliva proteomics updates in biomedicine

Journal of Biological Research - Thessaloniki, 2019
In the years of personalized (or precision) medicine the ‘omics’ methodologies in biomedical sciences—genomics, transcriptomics, proteomics and metabolomics—are helping researchers to detect quantifiable biological characteristics, or biomarkers, that ...
Katerina R. Katsani, Dimitra Sakellari
doaj   +1 more source