Results 101 to 110 of about 16,651,738 (349)
Pipettes and Pipelines: The Weapons of Omics Sciences for a New Age of Clinical Studies
Current Issues in Molecular BiologyThe omics sciences represent a revolution for clinical studies, offering integrative approaches to analyzing biological data with unprecedented depth. From the discovery of the double-helix structure of DNA to the CRISPR-Cas9 gene editing tool, passing ...
Ícaro S. Lopes +5 more
doaj +1 more source
Bioorganic & Medicinal Chemistry Letters, 2014 The unnatural amino acids (UAAs) are members of a class of molecules with relevant impacts in the life sciences. Due to the role of these molecules in the modulation of the chemical and physical properties of biological and inorganic materials, UAAs have
A. Stevenazzi +4 more
semanticscholar +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Estimating trauma prevalence from incomplete human skeletal remains
Scientific ReportsTraumatic lesions on human skeletal remains are widely used for reconstructing past accidents or violent encounters and for comparing trauma prevalence across samples over time and space.
Judith Beier +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Biological Network Inference: A Review of Methods and Assessment of Tools and Techniques
, 2014 The topic of reconstruction of genetic networks is of great interest to the scientific community today – particularly those in the biological sciences. Essentially the need for network reconstruction is motivated by the need to find relationships between
J. Omony
semanticscholar +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2019 Systems Pharmacology integrates structural biological and pharmacological knowledge and experimental data enabling dissection of organism and drug properties and providing excellent predictivity.
J. Lippert +18 more
semanticscholar +1 more source