Results 81 to 90 of about 507,580 (307)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The GF-NEO discovery platform unveils a [KQE][DG] sequence motif within fusion neoantigens in pediatric cancer

iScience
Summary: Gene fusions (GFs) are critical events in pediatric oncology, often serving as oncogenic drivers. However, fusion proteins and their derived neoantigens (GF-NEOs) remain underexplored for targeted immunotherapy.
Christopher Savoie, Zhaoguan Wu, Frederic Saab, Tristan St-Laurent, Lou Nielly Thibault, Charles B. Beauparlant, Marc-André Déry, Nehme El-Hachem, Bayrem Gharsallaoui, Samuel-Joseph Tremblay, Anna Sabouret, Nadia Emely Chauca Torres, Mélanie Bilodeau, Éric Bonneil, John Sidney, Alessandro Sette, Arnaud Droit, Pierre Thibault, Sonia Cellot, Étienne Caron, Isabelle Sirois   +20 more
doaj   +1 more source

Benchmarking selected computational gene network growing tools in context of virus-host interactions

, 2017
Several available online tools provide network growing functions where an algorithm utilizing different data sources suggests additional genes/proteins that should connect an input gene set into functionally meaningful networks.
Maurer-Stroh, S, Candida Vaz, Kuznetsov, Vladimir A., Vaz, Candida, Eisenhaber, Frank, Sugrue, Richard J., Sugrue, R.J, Richard J. Sugrue, Vaz, C, Kuznetsov, V.A, Tanavde, Vivek, Vivek Tanavde, Eisenhaber, F, Frank Eisenhaber, Biruhalem Taye, Taye, Biruhalem, Sebastian Maurer-Stroh, Tanavde, V, Taye, B, Maurer-Stroh, Sebastian, Vladimir A. Kuznetsov   +20 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Integrative activities content (aic): an auxiliary tool for the teaching of Biochemistry in the course of biological sciences at UFRN

Revista de Ensino de Bioquímica, 2015
There are constant changes in the development of science, technology, politics, culture and society; the need for change is also evident in the training of teachers. The ease of access to information makes us realize that traditional teaching needs to be updated.
F. D. Silva, J. K.S. Nascimento, M. V.S. Medeiros, L. D.M. Matta, R. V.C. Lima, V. D.S. Ferreira, L. G.A. Filgueira, G. P.V. Andrade   +7 more
openaire   +2 more sources

Impact of Iron Deficiency on the Growth and Bioelectrical Profile of Different Gut Bacteria

MicrobiologyOpen
Scope: Iron deficiency (ID) is the most common nutritional deficiency worldwide, impacting gut bacteria's metabolism and cellular biochemistry, but its effects on the microbiota‐gut‐brain axis (MGB) are poorly understood.
Elisa Quarta, Marwane Bourqqia‐Ramzi, David Muñoz‐Rodriguez, María Teresa García‐Esteban, Antonio Murciano‐Cespedosa, Álvaro Mateos González, Francisco José Conejero‐Meca, Juan Lombardo‐Hernandez, Jesús Mansilla‐Guardiola, Simona Baroni, Simonetta Geninatti Crich, Stefano Geuna, Luca Munaron, Deborah Chiabrando, Celia Herrera‐Rincon   +14 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Community-based Linking of Biological Network Resources: Databases, Formats and Tools

Journal of Integrative Bioinformatics, 2007
The analysis of biological networks is increasingly important in the life sciences and in particular in systems biology. Computer-based analysis tools are exploited for the investigation of these networks.
Telgkamp Michael, Koschützki Dirk, Schwöbbermeyer Henning, Schreiber Falk   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source