Results 121 to 130 of about 16,651,738 (349)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Du déterminisme biologique au déterminisme social
Socio, 2016 Historical semantics, while being opposed to the idea of linear progress, does enable us to show that notions of biological determinism and social determinism were broadly conceived as being complementary.
Marc Joly
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Focused Ion Beam in the Study of Biomaterials and Biological Matter
Advances in Materials Science and Engineering, 2012 The application of focused ion beam (FIB) techniques in the life sciences has progressed by leaps and bounds over the past decade. A once dedicated ion beam instrument, the focused ion beam today is generally coupled with a plethora of complementary ...
Kathryn Grandfield, Håkan Engqvist
doaj +1 more source
Accurate and Efficient Mapping of the Cross-Linked microRNA-mRNA Duplex Reads
iScience, 2019 Summary: MicroRNA (miRNA) trans-regulates the stability of many mRNAs and controls their expression levels. Reconstruction of the miRNA-mRNA interactome is key to the understanding of the miRNA regulatory network and related biological processes. However,
Cuncong Zhong, Shaojie Zhang
doaj +1 more source
Journal of Microbiology & Biology EducationABSTRACT Biology education in U.S. elementary schools faces challenges, including declining science proficiency and disparities among minority students. Limited resources, outdated materials, and a shortage of qualified educators hinder efforts to deliver engaging and ...
Phillip R. Myer, Jennie L. Zambito Ivey
openaire +2 more sources
Identification of Evidence-Based Biospecimen Quality-Control Tools
The Journal of Molecular Diagnostics, 2013 Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is lacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature ...
Betsou, Fotini +10 more
openaire +3 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source