Results 121 to 130 of about 1,815,049 (345)

BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models [PDF]

open access: yes, 2010
Background: Quantitative models of biochemical and cellular systems are used to answer a variety of questions in the biological sciences. The number of published quantitative models is growing steadily thanks to increasing interest in the use of models
Chelliah, Vijayalakshmi   +13 more
core   +5 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

open access: yesFEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio   +9 more
wiley   +1 more source

Reproducible computational biology experiments with SED-ML - The Simulation Experiment Description Markup Language [PDF]

open access: yes, 2011
Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments.
Adams, Richard   +10 more
core   +5 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Concluding remarks: The importance of polymer science for biological systems [PDF]

open access: yes, 2008
The 139th Faraday Discussion covered many interesting subjects, divided into four sections: Cell Interactions; Membranes & Walls; Proteins and Polysaccharides; and Natural & Synthetic Polymers.
Tirrell, David
core   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Estimating trauma prevalence from incomplete human skeletal remains

open access: yesScientific Reports
Traumatic lesions on human skeletal remains are widely used for reconstructing past accidents or violent encounters and for comparing trauma prevalence across samples over time and space.
Judith Beier   +2 more
doaj   +1 more source

Fluorescent Proteins as Genetically Encoded FRET Biosensors in Life Sciences

open access: yesItalian National Conference on Sensors, 2015
Fluorescence- or Förster resonance energy transfer (FRET) is a measurable physical energy transfer phenomenon between appropriate chromophores, when they are in sufficient proximity, usually within 10 nm.
Bernhard Hochreiter   +2 more
semanticscholar   +1 more source

ARCAD, a structuring node in the French plant genetic resource conservation system [PDF]

open access: yes, 2013
Agriculture in France has a primal role in economy and in rural organization throughout a a very broad climatic and geographic distribution (mainland and overseas territories).
Glaszmann, Jean-Christophe   +2 more
core  

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