Focused Ion Beam in the Study of Biomaterials and Biological Matter
Advances in Materials Science and Engineering, 2012 The application of focused ion beam (FIB) techniques in the life sciences has progressed by leaps and bounds over the past decade. A once dedicated ion beam instrument, the focused ion beam today is generally coupled with a plethora of complementary ...
Kathryn Grandfield, Håkan Engqvist
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A Survey of e-Biodiversity: Concepts, Practices, and Challenges
, 2018 The unprecedented size of the human population, along with its associated economic activities, have an ever increasing impact on global environments. Across the world, countries are concerned about the growing resource consumption and the capacity of ...
Artur Ziviani +13 more
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
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Accurate and Efficient Mapping of the Cross-Linked microRNA-mRNA Duplex Reads
iScience, 2019 Summary: MicroRNA (miRNA) trans-regulates the stability of many mRNAs and controls their expression levels. Reconstruction of the miRNA-mRNA interactome is key to the understanding of the miRNA regulatory network and related biological processes. However,
Cuncong Zhong, Shaojie Zhang
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, 2010 The present paper, developed with a group of second period of Biology Degree, had as main objective analyze our experience in the utilization of interactive methodology as didactic tool. Questionnaires and interviews were used with students in the process of collecting data; besides participant observation.
Araújo, Monica Lopes Folena +2 more
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
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A First Exposure to Statistical Mechanics for Life Scientists: Applications to Binding [PDF]
Statistical mechanics is one of the most powerful and elegant tools in the quantitative sciences. One key virtue of statistical mechanics is that it is designed to examine large systems with many interacting degrees of freedom, providing a clue that it ...
Hernan G. Garcia +4 more
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
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Nano Schiff base and its metal complexes: Synthesis, Characterization tools, biological applications and molecular docking studies Walaa H. Mahmouda,b*, Ahmed M. Refaata, Gehad G. Mohameda, b a. Chemistry Department, Faculty of Science, Cairo University, Giza, 126103, Egypt b. Egypt Nanotechnology Center, Cairo University, 6th October City, Giza, El-Sheikh Zayed, 12588, Egypt [PDF]
, 2019 Walaa H. Mahmoud +2 more
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Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
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