Results 171 to 180 of about 1,815,049 (345)

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Biotecnological war conceptual evaluation tool for the biotechnology and protein chemistry teaching for undergraduate and postgraduate students in biological sciences

, 2018
Biochemistry in general is practically unanimous as a discipline with a high degree of difficulty, complex and boring. So, practical and creative play games as teaching methodology has been disseminated in several disciplines of biological sciences.
Toyama, Marcos Hikari, Gaeta, Henrique Hessel, Ortolan, Bruna Doimi, Bittencourt Rodrigues, Caroline Fabri, Costa, Caroline Ramos da Cruz, Belchor, Mariana Novo, Toyama, Daniela de Oliveira   +6 more
openaire   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Structure comparison and evenness test of biological communities: Several platform-independent computational tools [PDF]

Computational Ecology and Software
The comparison of structural difference between biological communities and the evenness or diversity test of biological communities are always the focus in community studies.
WenJun Zhang
doaj  

Nano Schiff base and its metal complexes: Synthesis, Characterization tools, biological applications and molecular docking studies Walaa H. Mahmouda,b*, Ahmed M. Refaata, Gehad G. Mohameda, b a. Chemistry Department, Faculty of Science, Cairo University, Giza, 126103, Egypt b. Egypt Nanotechnology Center, Cairo University, 6th October City, Giza, El-Sheikh Zayed, 12588, Egypt [PDF]

, 2019
Walaa H. Mahmoud, Ahmed Refaat, Gehad G. Mohamed   +2 more
openalex   +1 more source

Improved tools for biological sequence comparison.

Proceedings of the National Academy of Sciences of the United States of America, 1988
W. Pearson, D. Lipman
semanticscholar   +1 more source

The pedagogical benefits and pitfalls of applying tools for teaching and learning laboratory practices in the biological sciences

, 2016
The aim of this study is to research the different methods used by biology teachers and their effects on the success of the students. Three student groups of biology students in University “GoceDelcev”, Faculty of Natural and Technical Sciences, Institute of Biology, - Stip, R.
Stavreva Veselinovska, Snezana, Kirova, Snezana   +1 more
openaire   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source