Results 151 to 160 of about 507,580 (307)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Shared Principles Between the Computing and Biological Sciences
, 2018 The purpose of this workshop was to bring together leading biologists and computational scientists interested in exploring shared principles between computing and biology. These two communities have a shared history of mutual influence where the transfer
NSF Admin Account NSF (5540198)
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Photometric stereo training dataset with annotated leaf masks
, 2018 Automated leaf segmentation is a challenging area in computer vision. Recent advances in machine learning approaches allowed to achieve better results than traditional image processing techniques (Scharr et al., 2016; Mengye and Zemel, 2016); however ...
Scorza, Livia; id_orcid +3 more
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Advancing molecular tools for signal transduction studies in mammalian cells
, 2014 Despite their fundamental importance, the dynamics of signaling pathways in living cells remain challenging to study, due to the lack of non-invasive tools for temporal assessment of signal transduction in desired cell models.
Afshari, Amirali
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Targeted knowledge: interaction and rich user experience towards a scholarly communication that "lets" [PDF]
, 2009 All living systems share many properties including hardly predictable behaviours, due to the differences between individuals and the chaos in natural environments.
G.Piero Pescarmona +3 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source