Results 51 to 60 of about 1,326,546 (323)

Simulation-based model selection for dynamical systems in systems and population biology [PDF]

, 2010
Computer simulations have become an important tool across the biomedical sciences and beyond. For many important problems several different models or hypotheses exist and choosing which one best describes reality or observed data is not straightforward ...
Addy, Arbouzova, Beaumont, Blum, Burnham, Chen, Clancy, Darnell, Del Moral, Eigen, Excoffier, Gelman, Gillespie, Grelaud, Gutenkunst, Horvath, Jeffreys, Kass, Kim, Kirk, Klingmüller, Köster, Longini, Marjoram, May, Michael P. H. Stumpf, Möller, Müller, O'Neill, Prusiner, Ratmann, Ratmann, Secrier, Sisson, Swameye, Timmer, Tina Toni, Toni, Vyshemirsky, Wei, Wilkinson, Zi   +41 more
core   +3 more sources

A robust vessel-labeling pipeline with high tissue clearing compatibility for 3D mapping of vascular networks

iScience
Summary: The combination of vessel-labeling, tissue-clearing, and light-sheet imaging techniques provides a potent tool for accurately mapping vascular networks, enabling the assessment of vascular remodeling in vascular-related disorders.
Yating Deng, Jingtan Zhu, Xiaomei Liu, Junyao Dai, Tingting Yu, Dan Zhu   +5 more
doaj   +1 more source

Genomic Transformation of the Picoeukaryote Ostreococcus tauri [PDF]

, 2012
Common problems hindering rapid progress in Plant Sciences include cellular, tissue and whole organism complexity, and notably the high level of genomic redundancy affecting simple genetics in higher plants. The novel model organism Ostreococcus tauri is
Bouget, François-Yves, Kis, Katalin, Knox, Kirsten, Millar, Andrew J, van Ooijen, Gerben   +4 more
core   +1 more source

Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo

iScience, 2019
Summary: RNA splicing is related to many human diseases; however, lack of efficient genetic approaches to modulate splicing has prevented us from dissecting their functions in human diseases.
Shisheng Huang, Zhaodi Liao, Xiangyang Li, Zhen Liu, Guanglei Li, Jianan Li, Zongyang Lu, Yu Zhang, Xiajun Li, Xu Ma, Qiang Sun, Xingxu Huang   +11 more
doaj   +1 more source

Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways

iScience, 2020
Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents.
Hengqian Ren, Chengyou Shi, Huimin Zhao
doaj   +1 more source

Single-molecule fluorescence microscopy review : shedding new light on old problems [PDF]

, 2017
Fluorescence microscopy is an invaluable tool in the biosciences, a genuine workhorse technique offering exceptional contrast in conjunction with high specificity of labelling with relatively minimal perturbation to biological samples compared with many ...
Leake, Mark Christian, Shashkova, Sviatlana   +1 more
core   +1 more source

Interlaboratory consistency of SDC2 promoter methylation detection in colorectal cancer using the post-optimized materials

iScience
Summary: Fecal DNA-based Syndecan 2 (SDC2) methylation detection is a promising non-invasive strategy for early colorectal cancer (CRC) screening. In China, commercial assays for SDC2 methylation detection vary in sensitivity and specificity, yet there ...
Lijing Zhang, Duo Wang, Ziqiang Li, Guigao Lin, Jinming Li, Rui Zhang   +5 more
doaj   +1 more source

Label-free 3D-CLEM Using Endogenous Tissue Landmarks

iScience, 2018
Summary: Emerging 3D correlative light and electron microscopy approaches enable studying neuronal structure-function relations at unprecedented depth and precision.
Manja Luckner, Steffen Burgold, Severin Filser, Maximilian Scheungrab, Yilmaz Niyaz, Eric Hummel, Gerhard Wanner, Jochen Herms   +7 more
doaj   +1 more source

Why Biology is Beyond Physical Sciences? [PDF]

, 2016
In the framework of materialism, the major attention is to find general organizational laws stimulated by physical sciences, ignoring the uniqueness of Life.
Muni, Bhakti Vijnana, Shanta, Bhakti Niskama   +1 more
core   +1 more source

The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

iScience, 2019
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation.
Meghan J. O'Melia, Amanda W. Lund, Susan N. Thomas   +2 more
doaj   +1 more source