Results 71 to 80 of about 1,815,049 (345)

All-Optical Volumetric Physiology for Connectomics in Dense Neuronal Structures

open access: yesiScience, 2019
Summary: All-optical physiology (AOP) manipulates and reports neuronal activities with light, allowing for interrogation of neuronal functional connections with high spatiotemporal resolution. However, contemporary high-speed AOP platforms are limited to
Chiao Huang   +9 more
doaj   +1 more source

Small RNAs and extracellular vesicles: New mechanisms of cross-species communication and innovative tools for disease control

open access: yesPLoS Pathogens, 2019
1 Department of Microbiology and Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, California, United States of America, 2 Department of Biology, Ludwig-Maximilians University ...
Qiang Cai   +4 more
semanticscholar   +1 more source

MALVA: Genotyping by Mapping-free ALlele Detection of Known VAriants

open access: yesiScience, 2019
Summary: The amount of genetic variation discovered in human populations is growing rapidly leading to challenging computational tasks, such as variant calling.
Luca Denti   +4 more
doaj   +1 more source

Moving in the Dark: Enlightening the Spatial Population Ecology of European Cave Salamanders

open access: yesPopulation Ecology, EarlyView.
We assessed individual interactions, movement ecology and activity patterns of a subterranean population of Speleomantes strinatii, applying spatial capture–recapture modeling to a photographic dataset of 104 individuals. ABSTRACT Space use and movement are fundamental aspects of organisms' ecology, mirroring individual fitness, behavior, and life ...
Giacomo Rosa   +2 more
wiley   +1 more source

Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

open access: yesiScience, 2018
Summary: The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs directly to their ...
Diana C. Alcobia   +9 more
doaj   +1 more source

A First Exposure to Statistical Mechanics for Life Scientists [PDF]

open access: yes, 2007
Statistical mechanics is one of the most powerful and elegant tools in the quantitative sciences. One key virtue of statistical mechanics is that it is designed to examine large systems with many interacting degrees of freedom, providing a clue that it ...
Garcia, Hernan G.   +4 more
core  

Monostability and multistability of genetic regulatory networks with different types of regulation functions [PDF]

open access: yes, 2010
The official published version of the article can be found at the link below.Monostability and multistability are proven to be two important topics in synthesis biology and system biology. In this paper, both monostability and multistability are analyzed
Andrianantoandro   +42 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Architectural Principles for Characterizing the Performance of Antithetic Integral Feedback Networks

open access: yesiScience, 2019
Summary: As we begin to design increasingly complex synthetic biomolecular systems, it is essential to develop rational design methodologies that yield predictable circuit performance.
Noah Olsman   +2 more
doaj   +1 more source

Unlocking the potential of Google Earth as a tool in invasion science [PDF]

open access: yesBiological Invasions, 2013
Distribution data are central to many invasion science applications. The shortage of good information on the distribution of alien species and their spatial dynamics is largely attributable to the cost, effort and expertise required to monitor these species over large areas. Virtual globes, particularly Google Earth, are free and user-friendly software
Visser, Vernon   +3 more
openaire   +5 more sources

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