Results 91 to 100 of about 1,974,684 (305)

Water-soluble hybrid materials based on {Mo₆X₈}⁴⁺ (X = Cl, Br, I) cluster complexes and sodium polystyrene sulfonate [PDF]

, 2017
Development of water-soluble forms of octahedral molybdenum clusters {Mo₆X₈}⁴⁺ (X = Cl, Br, I) is strongly motivated by the tremendous potential that these complexes have for biological applications, namely as agents for bioimaging and photodynamic ...
Brylev, Konstantin, Brylev, Konstantin A., Edeleva, Mariya, Edeleva, Mariya V., Efremova, Olga A., Gyrylova, Svetlana, Gyrylova, Svetlana N., Kitamura, Noboru, Kurskaya, Olga, Kurskaya, Olga G., Mironov, Yuri, Mironov, Yuri V., Shestopalov, Alexander, Shestopalov, Alexander M., Shestopalov, Michael, Shestopalov, Michael A., Solovieva, Anastasiya, Solovieva, Anastasiya O., Svezhentseva, Ekaterina, Svezhentseva, Ekaterina V., Tsygankova, Alphiya, Tsygankova, Alphiya R., Vorotnikov, Yuri, Vorotnikov, Yuri A.   +23 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Tratamento da arterite de Takayasu Takayasu’s arteritis treatment

Revista Brasileira de Reumatologia, 2006
A arterite de Takayasu (AT) é uma vasculite granulomatosa crônica que envolve a aorta e seus principais ramos. A monitoração da atividade da doença e o melhor esquema terapêutico ainda têm sido um desafio para todos os que tratam estes pacientes ...
Alexandre Wagner Silva de Souza, Raissa Maria Sampaio Neves, Kathia Regina Oliveira, Emília Inoue Sato   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Dynamics of body composition indicators in patients with early rheumatoid arthritis during therapy with methotrexate and biological drugs (pilot study)

Научно-практическая ревматология
Aim – to evaluate the parameters of body composition in patients with early rheumatoid arthritis on the background of anti-inflammatory therapy after 24 weeks of follow-up.Material and methods.
Yu. N. Gorbunova, L. V. Kondratyeva, T. V. Popkova, N. V. Demin, A. V. Smirnov, E. L. Nasonov   +5 more
doaj   +1 more source

Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver [PDF]

, 2013
Proton relative biological effectiveness (RBE) is known to depend on the (alpha/beta)(x) of irradiated tissues, with evidence of similar to 60% variation over (alpha/beta)(x) values from 1-10 Gy.
Carabe, Alejandro, Espana Palomares, Samuel, Grassberger, Clemens, Paganetti, Harald   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Recommendations for the treatment of axial spondyloarthritis: An analysis of the updated ASAS/EULAR 2022 clinical guidelines

Научно-практическая ревматология
The article discusses the 2022 updated version of the collaborative ASAS/EULAR (Assessment in SpondyloArthritis international Society/European Alliance of Associations for Rheumatology) recommendations for the treatment of axial spondyloarthritis.
Sh. F. Erdes, T. V. Dubinina
doaj   +1 more source

Sleep-Wake Disorders and a Look at Insomnia through Biological and Behavioral Perspectives [PDF]

, 2017
Insomnia is defined by difficulties in falling asleep, maintaining sleep, and problems with early morning awakenings. Unfortunately, due to these symptoms daytime fatigue often follows.
Fontanarosa, Mia
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source