Results 71 to 80 of about 1,154,039 (314)

The Biological Therapy of Cancer [PDF]

, 1992
The current status of biological approaches to the therapy of malignancy is reviewed. Biological response modifiers have been used in immunobiological therapeutic strategies, as myelorestorative agents during chemotherapy, as modulators of cytotoxic ...
David R Parkinson
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Severe Asthma or Chronic Obstructive Pulmonary Disease with Eosinophilic Inflammation? From Uncertainty to Remission under Anti IL-5R Therapy

Medicina
Background and Objectives: Severe adult-onset eosinophilic asthma and COPD with eosinophilic inflammation are two entities with a similar clinical course and are sometimes difficult to differentiate in clinical practice, especially in patients with a ...
Bianca Oprescu, Oana Raduna, Stefan Mihaicuta, Stefan Frent   +3 more
doaj   +1 more source

Targeted therapies for the treatment of non-small-cell lung cancer: Monoclonal antibodies and biological inhibitors

Human Vaccines & Immunotherapeutics, 2017
The usual treatments for patients with non-small-cell lung cancer (NSCLC), such as advanced lung adenocarcinoma, are unspecific and aggressive, and include lung resection, radiotherapy and chemotherapy.
Ana P. S. Silva, Priscila V. Coelho, Maristella Anazetti, Patricia U. Simioni   +3 more
doaj   +1 more source

Use of biological therapy to enhance both virotherapy and adoptive t-cell therapy for cancer

, 2008
To protect viral particles from neutralization, sequestration, nonspecific adhesion, and mislocalization following systemic delivery, we have previously exploited the natural tumor-homing properties of antigen-specific CD8+ T cells.
Willmon, Candice, Selby, P., Thompson, J., Strome, Scott, Galivo, F., Strome, S., Willmon, C., Kottke, Timothy, Diaz, R. M., Barber, G. N., Kaluza, K., Harrington, Kevin, Chester, John D., Barber, Glen N, Kaluza, Karen, Vile, R. G., Wongthida, Phonphimon, Selby, Peter, Kottke, T., Wongthida, P., Diaz, Rosa M, Galivo, Feorillo, Vile, Richard G, Melcher, A., Pulido, J., Harrington, K., Thompson, Jill, Chester, John, Melcher, Alan, Pulido, Jose   +29 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Radiological outcomes in perianal fistulizing Crohn's disease: A systematic review and meta‐analysis

JGH Open, 2020
Perianal fistulas are a common and debilitating manifestation of Crohn's disease. Since the advent of biological agents, patient outcomes appear to have improved.
Tanya Lee, Eric Yong, Nik S Ding
doaj   +1 more source

Introduction to radionuclide therapy

, 2008
This introductory chapter is written for those who are new to the field and desire a short overview of the present status of clinical and preclinical radionuclide therapy. In particular, this chapter provides an overview of the radiophysical concepts and
Carlsson, Jörgen,
core  

Exploring the Biological and Physical Basis of Boron Neutron Capture Therapy (BNCT) as a Promising Treatment Frontier in Breast Cancer

, 2022
SIMPLE SUMMARY: BNCT is a biologically targeted, densely ionizing form of radiation therapy that allows for increased tumor cell kill, while reducing toxicity to surrounding normal tissues. Although BNCT has been investigated in the treatment of head and
Bush, Aaron F., Daniel M. Trifiletti, Saranya Chumsri, Beltran, Chris J., Vallow, Laura A., Trifiletti, Daniel M., Pooja Advani, Aaron F. Bush, Advani, Pooja, Seneviratne, Danushka, Chumsri, Saranya, Danushka Seneviratne, Laura A. Vallow, Chris J. Beltran   +13 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source