Results 61 to 70 of about 6,047,039 (310)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

LONG-TERM RETENTION RATE OF CERTOLIZUMAB PEGOL IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS: DATA FROM THE TURKBIO REGISTRY

Rheumatology Quarterly
Aim: Selecting the most effective treatment plan for a patient represents one of the most challenging issues in contemporary rheumatology. Clinicians must consider the long-term retention rate and the reasons for discontinuing candidate drugs.This study ...
Ahmet Karataş, Yavuz Pehlivan, Servet Akar, Soner Şenel, Aslıhan Avanoğlu Güler, Özgül Soysal Gündüz, Ayten Yazıcı, Sema Yılmaz, Rabia Pişkin Sağır, Nevsun İnanç, Gözde Yıldırım Çetin, Mehmet Pamir Atagündüz, Fatoş Önen   +12 more
doaj   +1 more source

Tratamento da arterite de Takayasu Takayasu’s arteritis treatment

Revista Brasileira de Reumatologia, 2006
A arterite de Takayasu (AT) é uma vasculite granulomatosa crônica que envolve a aorta e seus principais ramos. A monitoração da atividade da doença e o melhor esquema terapêutico ainda têm sido um desafio para todos os que tratam estes pacientes ...
Alexandre Wagner Silva de Souza, Raissa Maria Sampaio Neves, Kathia Regina Oliveira, Emília Inoue Sato   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dynamics of body composition indicators in patients with early rheumatoid arthritis during therapy with methotrexate and biological drugs (pilot study)

Научно-практическая ревматология
Aim – to evaluate the parameters of body composition in patients with early rheumatoid arthritis on the background of anti-inflammatory therapy after 24 weeks of follow-up.Material and methods.
Yu. N. Gorbunova, L. V. Kondratyeva, T. V. Popkova, N. V. Demin, A. V. Smirnov, E. L. Nasonov   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

BIOLOGICS IN DERMATOLOGIC THERAPY - AN UPDATE

Indian Journal of Dermatology, 2009
Biologics are protein molecules which are used in various diseases to target the specific points in the immunopathogenesis of the diseases. The molecules are produced by recombinant DNA technology. The molecules bind to the specific targets without interfering wtih rest of the pathogenetic pathways.
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Biologic drugs induced vitiligo: case reports and review of literature

Frontiers in Immunology
Biological drugs are extensively used to treat various inflammatory diseases, including psoriasis, atopic dermatitis (AD), and rheumatoid arthritis. While generally effective and safe, these therapies have been increasingly associated with secondary ...
Xinyi Shao, Tingqiao Chen, Xingyu Pan, Shuang Chen, Yangmei Chen, Jin Chen   +5 more
doaj   +1 more source