Results 61 to 70 of about 1,154,039 (314)

Gene Therapy for Regenerative Medicine

, 2023
The development of biological methods over the past decade has stimulated great interest in the possibility to regenerate human tissues. Advances in stem cell research, gene therapy, and tissue engineering have accelerated the technology in tissue and ...
Ghorbanali Sharifzadeh, Hossein Hosseinkhani, Abraham J. Domb, Victoria Nahum   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Immune checkpoint B7-H3 is a potential therapeutic target in prostate cancer

Discover Oncology
High expression of immune checkpoint molecule B7-H3 (CD276) in many cancer types makes it a promising immunotherapeutic target. Both coinhibitory and costimulatory effects of B7-H3 in tumors have been demonstrated, but the mechanism of B7-H3 immune ...
Qi Shen, Kaichen Zhou, Haosen Lu, Jielin Zhang, Qiqing Xu, Chengsi Zhang, Chunhua Yang, Lijun Mao   +7 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The effectiveness of targeted therapy of various genetically engineered biological drugs in the treatment of bronchial asthma [PDF]

Терапевтический архив
This article presents the experience of successfully switching therapy from omalizumab 150 mg to benralizumab 30 mg/1 ml in a patient with a combined allergic and eosinophilic phenotype in the presence of hypersensitivity to nonsteroidal anti ...
Madina S. Shogenova, Svetlana H. Hutueva, Laura S. Shogenova   +2 more
doaj   +1 more source

Cancer research and therapy: Where are we today?

, 2014
Till date scientists are struggling to understand the complete mechanism of carcinogenesis. In future, the real time detection of cancer may help scientists to identify some of the complicated biological mechanisms.
Sawant, Sampada; C.U. Shah College of Pharmacy, SNDT Women’s University, Juhu, Santacruz (West), Mumbai, India, Shegokar, Ranjita; Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Freie Universität Berlin, Berlin, Germany   +1 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Biological therapy of traditional therapy-resistant adult-onset Still’s disease: an evidence-based review

, 2018
Sha Zhou,* Jianjun Qiao,* Juan Bai, Yinhua Wu, Hong Fang Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China *These authors contributed equally to this
Fang H, Zhou S, Bai J, Qiao J, Wu Y
core  

3D Monte Carlo radiation transfer modelling of photodynamic therapy

, 2015
We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell as well as the Alfred Stewart Trust.The effects of ageing and skin type on Photodynamic Therapy (PDT) for ...
Wood, Kenneth, Valentine, Ronan M., Christison, C., C. Louise Campbell, Campbell, C. Louise, Kenneth Wood, Brown, C Tom A, Moseley, H., Moseley, Harry, C. Tom A. Brown, Campbell, Catherine Louise, Harry Moseley, Wood, Kenny, Brown, C. Tom A, Craig Christison, Ronan M. Valentine, Christison, Craig, Valentine, Ronan Martin   +17 more
core   +1 more source