Results 51 to 60 of about 5,744,468 (268)

Severe Asthma or Chronic Obstructive Pulmonary Disease with Eosinophilic Inflammation? From Uncertainty to Remission under Anti IL-5R Therapy

Medicina
Background and Objectives: Severe adult-onset eosinophilic asthma and COPD with eosinophilic inflammation are two entities with a similar clinical course and are sometimes difficult to differentiate in clinical practice, especially in patients with a ...
Bianca Oprescu, Oana Raduna, Stefan Mihaicuta, Stefan Frent   +3 more
doaj   +1 more source

Radiological outcomes in perianal fistulizing Crohn's disease: A systematic review and meta‐analysis

JGH Open, 2020
Perianal fistulas are a common and debilitating manifestation of Crohn's disease. Since the advent of biological agents, patient outcomes appear to have improved.
Tanya Lee, Eric Yong, Nik S Ding
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Biological therapy of traditional therapy-resistant adult-onset Still’s disease: an evidence-based review

, 2018
Sha Zhou,* Jianjun Qiao,* Juan Bai, Yinhua Wu, Hong Fang Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China *These authors contributed equally to this
Fang H, Zhou S, Bai J, Qiao J, Wu Y
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

LONG-TERM RETENTION RATE OF CERTOLIZUMAB PEGOL IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS: DATA FROM THE TURKBIO REGISTRY

Rheumatology Quarterly
Aim: Selecting the most effective treatment plan for a patient represents one of the most challenging issues in contemporary rheumatology. Clinicians must consider the long-term retention rate and the reasons for discontinuing candidate drugs.This study ...
Ahmet Karataş, Yavuz Pehlivan, Servet Akar, Soner Şenel, Aslıhan Avanoğlu Güler, Özgül Soysal Gündüz, Ayten Yazıcı, Sema Yılmaz, Rabia Pişkin Sağır, Nevsun İnanç, Gözde Yıldırım Çetin, Mehmet Pamir Atagündüz, Fatoş Önen   +12 more
doaj   +1 more source

Tratamento da arterite de Takayasu Takayasu’s arteritis treatment

Revista Brasileira de Reumatologia, 2006
A arterite de Takayasu (AT) é uma vasculite granulomatosa crônica que envolve a aorta e seus principais ramos. A monitoração da atividade da doença e o melhor esquema terapêutico ainda têm sido um desafio para todos os que tratam estes pacientes ...
Alexandre Wagner Silva de Souza, Raissa Maria Sampaio Neves, Kathia Regina Oliveira, Emília Inoue Sato   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1895

, 1896
Annual report of the Marine Biological Laboratory in Woods Hole. 1895.
Marine Biological Laboratory (Woods Hole MA)
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source