Results 141 to 150 of about 6,047,039 (310)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1981

, 1982
Annual report of the Marine Biological Laboratory in Woods Hole. 1981.
Marine Biological Laboratory (Woods Hole MA)
core  

Vitiligo onset following anti-inflammatory biological therapy: a scoping review. [PDF]

Front Immunol
Romagnuolo M, Moltrasio C, Rossi LC, Tavoletti G, Marzano AV, Alberti Violetti S.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1991

, 1992
Annual report of the Marine Biological Laboratory in Woods Hole. 1991.
Marine Biological Laboratory (Woods Hole MA)
core  

Correction to: Aptamer combined with fluorescent silica nanoparticles for detection of hepatoma cells

Discover Nano
Zixi Hu, Juntao Tan, Zongqiang Lai, Rong Zheng, Jianhong Zhong, Yiwei Wang, Xiaoxue Li, Nuo Yang, Jieping Li, Wei Yang, Yong Huang, Yongxiang Zhao, Xiaoling Lu   +12 more
doaj   +1 more source

SERPINE1 promoter variants and differential airway responses to virus and biological therapy. [PDF]

J Allergy Clin Immunol
Thames AH, Schutt M, Gadd S, Barrera L, Cho S, Wentworth-Sheilds W, Pongracic J, Liu AH, Gruchalla R, Kercsmar C, Hershey GK, Zoratti E, Johnson C, Teach S, Kattan M, Nodzenski M, Gaberino C, Bacharier L, O'Connor GT, Gern J, Visness C, Coleman A, Gergen P, Becker P, Ober C, Jackson D, Altman M, Kumar R.   +27 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1939

, 1940
Annual report of the Marine Biological Laboratory in Woods Hole. 1939.
Marine Biological Laboratory (Woods Hole MA)
core  

Proactive Tight Monitoring of Patients with Inflammatory Bowel Disease in Biological Therapy: A Controlled Clinical Study (TIME IT). [PDF]

J Clin Med
Christensen KR, Al-Obaidi OSA, Buhl S, Ilvemark JF, Steenholdt C, Brynskov J, Ainsworth MA.   +6 more
europepmc   +1 more source