Results 231 to 240 of about 1,154,039 (314)

Editorial: Biological therapy for allergic diseases: peculiarities, prospects, and challenges. [PDF]

Front Allergy
Mingomataj EÇ, Ibrahim T, Rizvi SA.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma. [PDF]

Eur Respir J
Khaleva E, Brightling C, Eiwegger T, Altraja A, Bégin P, Blumchen K, Bossios A, Bourdin A, Ten Brinke A, Brusselle G, Bumbacea RS, Bush A, Casale TB, Clarke GW, Chaudhuri R, Chung KF, Coleman C, Corren J, Dahlén SE, Deschildre A, Djukanovic R, Eger K, Exley A, Fleming L, Fowler SJ, Gaillard EA, Gappa M, Gupta A, Haitchi HM, Hashimoto S, Heaney LG, Hedlin G, Henderson M, Hua W, Jackson DJ, Karadag B, Katelaris CH, Koh MS, Kopp MV, Koppelman GH, Kull I, Kurukulaaratchy RJ, Lee JH, Mahler V, Mäkelä M, Masoli M, Mathioudakis AG, Mazon A, Melén E, Milger K, Moeller A, Murray CS, Nagakumar P, Nair P, Negus J, Nieto A, Papadopoulos NG, Paton J, Pijnenburg MW, Pike KC, Porsbjerg C, Rattu A, Rupani H, Rusconi F, Rutjes NW, Saglani S, Seddon P, Siddiqui S, Singer F, Tajiri T, Turner S, Upham JW, Vijverberg SJH, Wark PAB, Wechsler ME, Yasinska V, Roberts G, 3TR Asthma Definition of Response Working Group.   +77 more
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Biosimilars versus biological therapy in inflammatory bowel disease: challenges and targeting strategies using drug delivery systems. [PDF]

Clin Exp Med
Aljabri A, Soliman GM, Ramadan YN, Medhat MA, Hetta HF.   +4 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Optimization of biological therapy selection in rheumatoid arthritis: insights into anemia and interleukin-6 pathway. [PDF]

J Rheum Dis
Nam B.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Diffusion-weighted imaging to predict longer-term response in Crohn's disease patients commencing biological therapy: results from the MOTILITY trial. [PDF]

Br J Radiol
Hameed M, Taylor SA, Ahmed N, Chowdhury K, Patel A, Helbren E, Bhagwanani A, Hyland R, Bhatnagar G, Sidhu H, Lambie H, Franklin J, Mohsin M, Thomson E, Boone D, Tolan D, Rahman S, Sakai NS, Moran GW, Hart A, Bloom S, Menys A, Jacobs I, Halligan S, Plumb AA, MOTILITY Trial Investigators .   +25 more
europepmc   +1 more source